Thiolutin (CAS 87-11-6)
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Thiolutin is a sulfur-containing compound with a dithiolopyrrolone structure, notable in antifungal and antibacterial research. In research applications, thiolutin is utilized to probe the function of RNA polymerases, as it is known to inhibit both prokaryotic and eukaryotic RNA polymerase activities. This inhibition is for understanding the transcriptional processes within cells and the effects of transcriptional disruption. Studies involving thiolutin have shed light on the complex interplay between transcription factors and RNA polymerases, providing valuable insights into gene expression regulation. Furthermore, thiolutin′s ability to halt the synthesis of mRNA offers a method to explore the cellular responses to transcriptional stress, including the examination of stress response pathways and the identification of compounds with potential regulatory roles.
Thiolutin (CAS 87-11-6) References
- Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. | Minamiguchi, K., et al. 2001. Int J Cancer. 93: 307-16. PMID: 11433393
- In vivo effect of thiolutin on cell growth and macromolecular synthesis in Escherichia coli. | Khachatourians, GG. and Tipper, DJ. 1974. Antimicrob Agents Chemother. 6: 304-10. PMID: 15830477
- Determination of mRNA half-lives in Candida albicans using thiolutin as a transcription inhibitor. | Kebaara, BW., et al. 2006. Genome. 49: 894-9. PMID: 17036064
- The transcriptional inhibitor thiolutin blocks mRNA degradation in yeast. | Pelechano, V. and Pérez-Ortín, JE. 2008. Yeast. 25: 85-92. PMID: 17914747
- Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin. | Dai, S., et al. 2008. J Proteome Res. 7: 4384-95. PMID: 18720982
- Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. | Jia, Y., et al. 2010. Cell Stress Chaperones. 15: 165-81. PMID: 19579057
- Regulation of biosynthesis of thiolutin and aureothricin in Streptomyces kasugaensis. | Sturdíková, M., et al. 1990. Folia Microbiol (Praha). 35: 278-83. PMID: 2262169
- Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway. | Zhai, Y., et al. 2016. Biochem Biophys Res Commun. 473: 329-335. PMID: 27018252
- The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. | Zhou, W., et al. 2020. J Nat Prod. 83: 202-209. PMID: 32049520
- Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885. | Song, F., et al. 2022. Mar Drugs. 20: PMID: 35323513
- POH1/Rpn11/PSMD14: a journey from basic research in fission yeast to a prognostic marker and a druggable target in cancer cells. | Spataro, V. and Buetti-Dinh, A. 2022. Br J Cancer. 127: 788-799. PMID: 35501388
- Inhibition of yeast ribonucleic acid polymerases by thiolutin. | Tipper, DJ. 1973. J Bacteriol. 116: 245-56. PMID: 4583213
- Mapping of two transcription mutations (tlnI and tlnII) conferring thiolutin resistance, adjacent to dnaZ and rho in Escherichia coli. | Sivasubramanian, N. and Jayaraman, R. 1980. Mol Gen Genet. 180: 609-15. PMID: 7007825
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiolutin, 1 mg | sc-200387 | 1 mg | $101.00 | |||
Thiolutin, 5 mg | sc-200387A | 5 mg | $406.00 |