Molecular structure of Thiocolchicoside, CAS Number: 602-41-5
Thiocolchicoside (CAS 602-41-5)
Alternate Names:
2-Demethoxy-2-glucosidoxythiocolchicine
Application:
Thiocolchicoside is a GABAA receptor antagonist
CAS Number:
602-41-5
Purity:
>95%
Molecular Weight:
563.6
Molecular Formula:
C27H33NO10S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Thiocolchicoside is a small molecule muscle relaxant and anti-inflammatory agent, shown to function as a competitive GABAA (gamma-aminobutyric acid type A) receptor antagonist. Thiocolchicoside is also shown to inhibit strychnine-sensitive GlyR (glycine receptors)with lower potency than GABAA, and to inhibit human AChR (nicotinic acetylcholine receptors) with very low relative affinity.
Thiocolchicoside (CAS 602-41-5) References
- Characterization of [3H]thiocolchicoside binding sites in rat spinal cord and cerebral cortex. | Balduini, W., et al. 1999. Eur J Pharmacol. 376: 149-57. PMID: 10440100
- Autoradiographic localization of [3H]thiocolchicoside binding sites in the rat brain and spinal cord. | Balduini, W., et al. 2001. Neuropharmacology. 40: 1044-9. PMID: 11406196
- Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat. | Sechi, G., et al. 2003. Seizure. 12: 508-15. PMID: 12967581
- Effect of chemical enhancers and iontophoresis on thiocolchicoside permeation across rabbit and human skin in vitro. | Artusi, M., et al. 2004. J Pharm Sci. 93: 2431-8. PMID: 15349953
- The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system. | Carta, M., et al. 2006. Neuropharmacology. 51: 805-15. PMID: 16806306
- Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes. | Mascia, MP., et al. 2007. Eur J Pharmacol. 558: 37-42. PMID: 17234181
- Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: an in vitro study. | Akkemik, E., et al. 2010. J Enzyme Inhib Med Chem. 25: 871-5. PMID: 21054237
- The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit. | Kertmen, H., et al. 2012. Acta Neurochir (Wien). 154: 1431-6. PMID: 22722379
- Evaluation of the effect of mesotherapy in the management of back pain in police working dog. | Alves, JC., et al. 2018. Vet Anaesth Analg. 45: 123-128. PMID: 29222031
- A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs. | Alves, JC., et al. 2022. Am J Vet Res. 84: PMID: 36367787
- Structure of colchioside. X-ray analysis of thiocolchicoside, the sulfur analogue of the glucoside of colchicine. | Clark, JI. and Margulis, TN. 1980. Life Sci. 26: 833-6. PMID: 7374349
- Binding of colchicine and thiocolchicoside to human serum proteins and blood cells. | Sabouraud, A., et al. 1994. Int J Clin Pharmacol Ther. 32: 429-32. PMID: 7981928
- Interaction of thiocolchicoside with [3H]strychnine binding sites in rat spinal cord and brainstem. | Cimino, M., et al. 1996. Eur J Pharmacol. 318: 201-4. PMID: 9007533
Inhibitor of:
β3 Tubulin, γ2 Tubulin, C12orf23, DNCLI1, GABA Receptor, karyopherin β2B, NDEL1, NF-M, SEC16S, and TBCD.Activator of:
γ Tubulin, AChR, and GlyR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiocolchicoside, 1 mg | sc-202839 | 1 mg | $30.00 | |||
Thiocolchicoside, 5 mg | sc-202839A | 5 mg | $120.00 |