Thioaildenafil (CAS 856190-47-1)
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Thioaildenafil operates by selectively targeting and inhibiting the enzyme phosphodiesterase-5 (PDE-5), which is primarily responsible for the hydrolysis of cyclic guanosine monophosphate (cGMP) into its inactive form. Under normal conditions, cGMP plays a pivotal role in cellular signaling processes, but its breakdown by PDE-5 can attenuate these signals. When thioaildenafil inhibits PDE-5, it effectively prevents the degradation of cGMP, thereby sustaining enhanced levels of this cyclic nucleotide within cellular environments. This modulation of cGMP levels is in research applications where understanding the biochemical pathways and signaling mechanisms influenced by cGMP is essential. Thus, thioaildenafil serves as useful in biochemical and physiological studies, enabling researchers to explore the intricate dynamics of cGMP-dependent pathways and their effects on various cellular functions.
Thioaildenafil (CAS 856190-47-1) References
- Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs. | Reepmeyer, JC. and d'Avignon, DA. 2009. J Pharm Biomed Anal. 49: 145-50. PMID: 19042103
- 2D and 3D DOSY 1H NMR, a useful tool for analysis of complex mixtures: application to herbal drugs or dietary supplements for erectile dysfunction. | Balayssac, S., et al. 2009. J Pharm Biomed Anal. 50: 602-12. PMID: 19108978
- Structural characterization of sulfoaildenafil, an analog of sildenafil. | Gratz, SR., et al. 2009. J Pharm Biomed Anal. 50: 228-31. PMID: 19427155
- Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis. | Demizu, Y., et al. 2011. Chem Pharm Bull (Tokyo). 59: 1314-6. PMID: 21963647
- Assessing supplement safety--the FDA's controversial proposal. | Cohen, PA. 2012. N Engl J Med. 366: 389-91. PMID: 22276780
- FDA faces barrage of criticism over plans to assess safety of supplements. | Epstein, K. 2012. BMJ. 344: e583. PMID: 22277134
- Differentiation between sulfoaildenafil and its analogs. | Moriyasu, T., et al. 2011. J AOAC Int. 94: 1770-7. PMID: 22320083
- Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements. | Kee, CL., et al. 2012. J Pharm Biomed Anal. 70: 265-72. PMID: 22840979
- Analysis of illicit dietary supplements sold in the Italian market: identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS. | Damiano, F., et al. 2014. Sci Justice. 54: 228-37. PMID: 24796952
- Simultaneous Detection of Three Phosphodiesterase Type 5 Inhibitors and Eight of Their Analogs in Lifestyle Products and Screening for Adulterants by High-Performance Thin-Layer Chromatography. | Do, TT., et al. 2015. J AOAC Int. 98: 1226-33. PMID: 26525240
- [Rapid screening and confirmation of illegally added anti- impotence preparations in health care products by high performance liquid chromatography-high resolution mass spectrometry]. | Hu, T., et al. 2015. Se Pu. 33: 897-901. PMID: 26749869
- Mining Adverse Events of Dietary Supplements from Product Labels by Topic Modeling. | Wang, Y., et al. 2017. Stud Health Technol Inform. 245: 614-618. PMID: 29295169
- Structural Determination, Biological Function, and Molecular Modelling Studies of Sulfoaildenafil Adulterated in Herbal Dietary Supplement. | Kodchakorn, K., et al. 2021. Molecules. 26: PMID: 33670094
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thioaildenafil, 5 mg | sc-474390 | 5 mg | $496.00 |