Date published: 2026-4-19

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Thidiazuron (CAS 51707-55-2)

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Alternate Names:
Thidiauron; 1-phenyl-3-(thiadiazol-5-yl)urea; TDZ
Application:
Thidiazuron is a urea derivative which acts as a cytokinin-active plant growth regulator
CAS Number:
51707-55-2
Purity:
≥97%
Molecular Weight:
220.25
Molecular Formula:
C9H8N4OS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Thidiazuron (TDZ), classified as a synthetic cytokinin plant hormone, finds extensive application in plant tissue culture, plant biotechnology, and plant breeding. Belonging to the benzyladenine group of plant hormones, it stands out for its capacity to rapidly initiate shoot regeneration in plants. Thidiazuron′s utility extends to stimulating embryogenesis, somatic embryogenesis, and organogenesis in plants. Additionally, it fosters adventitious root growth, triggers flowering, and promotes the formation of callus and protoplasts in plants. Its versatility shines as a potent plant hormone with a broad spectrum of uses in plant biotechnology, breeding, and tissue culture.The scientific realm has embraced Thidiazuron for comprehensively studying the influence of plant hormones on plant growth and development. It serves as a tool for examining cytokinins′ impacts on growth, delving into somatic embryo and adventitious root evolution, and exploring callus and protoplast development. Investigations into flowering induction have also hinged on Thidiazuron′s properties. Mechanistically, Thidiazuron binds to plant cell cytokinin receptor proteins, subsequently triggering a cascade of biochemical and physiological reactions within the plant. This engagement has been correlated with elevated gene expressions linked to cell division and expansion, along with augmented protein synthesis tied to cell wall extension. Furthermore, it stimulates the synthesis of auxins and gibberellins, pivotal for governing plant growth and development.


Thidiazuron (CAS 51707-55-2) References

  1. Novel thidiazuron-derived inhibitors of cytokinin oxidase/dehydrogenase.  |  Nisler, J., et al. 2016. Plant Mol Biol. 92: 235-48. PMID: 27422623
  2. Identification, Synthesis, and Safety Assessment of Thidiazuron [1-Phenyl-3-(1,2,3-thidiazol-5-yl)urea] and Its Metabolites in Kiwifruits.  |  Zhang, Z., et al. 2017. J Agric Food Chem. 65: 11273-11279. PMID: 29144740
  3. Thidiazuron-induced abnormalities in plant tissue cultures.  |  Dewir, YH., et al. 2018. Plant Cell Rep. 37: 1451-1470. PMID: 30051285
  4. The Morphoregulatory Role of Thidiazuron: Metabolomics-Guided Hypothesis Generation for Mechanisms of Activity.  |  Erland, LAE., et al. 2020. Biomolecules. 10: PMID: 32872300
  5. Thidiazuron suppresses breast cancer via targeting miR-132 and dysregulation of the PI3K-Akt signaling pathway mediated by the miR-202-5p-PTEN axis.  |  Ibrahim, HM., et al. 2021. Biochem Cell Biol. 99: 374-384. PMID: 33103467
  6. Thidiazuron decreases epithelial-mesenchymal transition activity through the NF-kB and PI3K/AKT signalling pathways in breast cancer.  |  Rajendran, P., et al. 2020. J Cell Mol Med. 24: 14525-14538. PMID: 33159487
  7. Thidiazuron-induced direct organogenesis from immature inflorescence of three date palm cultivars.  |  Taha, RA., et al. 2021. J Genet Eng Biotechnol. 19: 14. PMID: 33474639
  8. A Cytokinin Analog Thidiazuron Suppresses Shoot Growth in Potted Rose Plants via the Gibberellic Acid Pathway.  |  Çelikel, FG., et al. 2021. Front Plant Sci. 12: 639717. PMID: 34335639
  9. The multipotent thidiazuron: A mechanistic overview of its roles in callogenesis and other plant cultures in vitro.  |  Ali, HM., et al. 2022. Biotechnol Appl Biochem. 69: 2624-2640. PMID: 35048414
  10. Thidiazuron Promotes Leaf Abscission by Regulating the Crosstalk Complexities between Ethylene, Auxin, and Cytokinin in Cotton.  |  Li, F., et al. 2022. Int J Mol Sci. 23: PMID: 35269837
  11. Thidiazuron: New Trends and Future Perspectives to Fight Xylella fastidiosa in Olive Trees.  |  Catalano, A., et al. 2022. Antibiotics (Basel). 11: PMID: 35884201
  12. Thidiazuron and LED Lighting Enhance Taxifolin and Rutin Production in Rhododendron mucronulatum Turcz. Microshoot Culture.  |  Zaytseva, Y., et al. 2023. J Plant Growth Regul. 42: 2933-2942. PMID: 35975274
  13. Thidiazuron, a phenyl-urea cytokinin, inhibits ergosterol synthesis and attenuates biofilm formation of Candida albicans.  |  Harikrishnan, P., et al. 2022. World J Microbiol Biotechnol. 38: 224. PMID: 36114903
  14. Study on exogenous application of thidiazuron on seed size of Brassica napus L.  |  Zhai, L., et al. 2022. Front Plant Sci. 13: 998698. PMID: 36147221

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Thidiazuron, 250 mg

sc-251228
250 mg
$114.00