Molecular structure of Thiazolyl Blue, CAS Number: 298-93-1
Thiazolyl Blue (CAS 298-93-1)
See product citations (40)
Alternate Names:
Thiazolyl Blue is also known at MTT, MMT Tetrazolium, and Thiazolyl Blue Tetrazolium Bromide
Application:
Thiazolyl Blue may be used in measurement of cell proliferation and is a membrane-permeable dye reduced by mitochondrial enzymes
CAS Number:
298-93-1
Purity:
≥98%
Molecular Weight:
414.32
Molecular Formula:
C18H16BrN5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Thiazolyl Blue is a membrane-permeable yellow dye that is reduced by mitochondrial reductases in living cells to form the dark blue product, MTT Formazan (sc-215399). Spectrophotometric measurement of MTT Formazan at 540 or 570 nm allows quantitation of cell viability. Thiazolyl Blue is used as a direct indicator of cytotoxicity (such as for screening cancer drugs) and apoptosis. It is also an electron acceptor used for studying NADP-dependent dehydrogenases.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Thiazolyl Blue (CAS 298-93-1) References
- Toxicity hazard of organophosphate insecticide malathion identified by in vitro methods. | Jira, D., et al. 2012. Neuro Endocrinol Lett. 33 Suppl 3: 53-9. PMID: 23353844
- Cytotoxic, genotoxic/antigenotoxic and mutagenic/antimutagenic effects of the venom of the wasp Polybia paulista. | Hoshina, MM., et al. 2013. Toxicon. 72: 64-70. PMID: 23796727
- Compounds used to produce cloned animals are genotoxic and mutagenic in mammalian assays in vitro and in vivo. | Oliveira, RJ., et al. 2014. Braz J Med Biol Res. 47: 287-98. PMID: 24714812
- Cytotoxic and genotoxic effects of ethanolic extract of Euphorbia hyssopifolia L. on HepG2 cells. | Araújo, Sde S., et al. 2015. J Ethnopharmacol. 170: 16-9. PMID: 25937254
- Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target. | Liu, G., et al. 2015. Int J Clin Exp Pathol. 8: 1402-10. PMID: 25973024
- Cytotoxic and genotoxic effects of two hair dyes used in the formulation of black color. | Tafurt-Cardona, Y., et al. 2015. Food Chem Toxicol. 86: 9-15. PMID: 26404083
- CRISPR-Cas9 Mediated NOX4 Knockout Inhibits Cell Proliferation and Invasion in HeLa Cells. | Jafari, N., et al. 2017. PLoS One. 12: e0170327. PMID: 28099519
- Megastigmane glucosides isolated from Dichrocephala benthamii. | Song, B., et al. 2017. Chin J Nat Med. 15: 288-291. PMID: 28527514
- Recombinant elastin-based nanoparticles for targeted gene therapy. | Monfort, DA. and Koria, P. 2017. Gene Ther. 24: 610-620. PMID: 28681841
- Optimum morphology of gold nanorods for light-induced hyperthermia. | Morales-Dalmau, J., et al. 2018. Nanoscale. 10: 2632-2638. PMID: 29355866
- Evaluation of the potential agricultural use of biostimulated sewage sludge using mammalian cell culture assays. | Sommaggio, LRD., et al. 2018. Chemosphere. 199: 10-15. PMID: 29427809
- Unravelling the Potential Cytotoxic Effects of Metal Oxide Nanoparticles and Metal(Loid) Mixtures on A549 Human Cell Line. | Rosário, F., et al. 2020. Nanomaterials (Basel). 10: PMID: 32131449
- PBAT biodegradable mulch films: Study of ecotoxicological impacts using Allium cepa, Lactuca sativa and HepG2/C3A cell culture. | Souza, PMS., et al. 2020. Chemosphere. 256: 126985. PMID: 32445994
- New Broth Macrodilution Volatilization Method for Antibacterial Susceptibility Testing of Volatile Agents and Evaluation of Their Toxicity Using Modified MTT Assay In Vitro. | Houdkova, M., et al. 2021. Molecules. 26: PMID: 34299454
- An in vitro study on the efficacy of hydrogen peroxide mediated high-power photodynamic therapy affecting Enterococcus faecalis biofilm formation and dispersal. | Afrasiabi, S. and Chiniforush, N. 2023. Photodiagnosis Photodyn Ther. 41: 103310. PMID: 36720360
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NOXO1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiazolyl Blue, 1 g | sc-359848 | 1 g | $115.00 | |||
Thiazolyl Blue, 5 g | sc-359848A | 5 g | $275.00 | |||
Thiazolyl Blue, 25 g | sc-359848B | 25 g | $991.00 | |||
Thiazolyl Blue, 100 g | sc-359848C | 100 g | $3215.00 |