Molecular structure of Thiazolidinedione derivative
Thiazolidinedione derivative
Application:
Thiazolidinedione derivative is a potent 15-PGDH activity inhibitor
Molecular Weight:
331.4
Molecular Formula:
C16H13NO3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity. Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity. Thiazolidinedione derivative is a TZD derivative that inhibits 15-PGDH activity with an IC50 value of 31 nM.
Thiazolidinedione derivative References
- 15-hydroxyprostaglandin dehydrogenase. A review. | Hansen, HS. 1976. Prostaglandins. 12: 647-79. PMID: 184496
- Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors. | Wu, Y., et al. 2010. Bioorg Med Chem. 18: 1428-33. PMID: 20122835
Activator of:
PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiazolidinedione derivative, 5 mg | sc-358842 | 5 mg | $107.00 | |||
Thiazolidinedione derivative, 10 mg | sc-358842A | 10 mg | $203.00 |