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Thiazole orange (CAS 107091-89-4)

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Alternate Names:
Thiazole orange also known as 1-Methyl-4-[(3-methyl-2(3H)-benzothiazolylidene)methyl]quinolinium p-tosylate; 4-(3-Methyl-2,3-dihydro-(benzo-1,3-thiazole)-2-methylidene)-quinolinium iodide
Application:
Thiazole orange is a fluorescent dye for DNA staining which is used for reticulocyte analysis and Plasmodium species analysis
CAS Number:
107091-89-4
Molecular Weight:
476.61
Molecular Formula:
C26H24N2O3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Thiazole Orange is a fluorescent dye DNA stain used for reticulocyte analysis. Thiazole orange can also be potentially useful for Plasmodium species analysis. Thiazole orange when bonded with nucleic acids have fluorescence enhancement and a high yield. Thiazole orange is non precipitating and has the ability to permeate through live cell membranes. Thiazole orange can be used for quantification of reticulocytes.


Thiazole orange (CAS 107091-89-4) References

  1. Thiazole orange: a new dye for reticulocyte analysis.  |  Lee, LG., et al. 1986. Cytometry. 7: 508-17. PMID: 2430763
  2. Ebola virus derived G-quadruplexes: Thiazole orange interaction.  |  Krafčíková, P., et al. 2017. Biochim Biophys Acta Gen Subj. 1861: 1321-1328. PMID: 27979676
  3. Thiazole Orange as an Alternative to Antibody Binding for Detecting Triple-helical DNA in Heterochromatin of Drosophila and Rhynchosciara.  |  Gorab, E. and Pearson, PL. 2018. J Histochem Cytochem. 66: 143-154. PMID: 29268630
  4. Thiazole orange as an everyday replacement for ethidium bromide and costly DNA dyes for electrophoresis.  |  O'Neil, CS., et al. 2018. Electrophoresis. 39: 1474-1477. PMID: 29645293
  5. DNA Electrophoresis Using Thiazole Orange Instead of Ethidium Bromide or Alternative Dyes.  |  O'Neil, CS., et al. 2019. J Vis Exp.. PMID: 30985761
  6. Thiazole orange - Spermine conjugate: A potent human telomerase inhibitor comparable to BRACO-19.  |  Wang, S., et al. 2019. Eur J Med Chem. 175: 20-33. PMID: 31071547
  7. Photophysics of thiazole orange in deep eutectic solvents.  |  Kumar Gautam, R., et al. 2021. Spectrochim Acta A Mol Biomol Spectrosc. 258: 119812. PMID: 33905961
  8. Broad Applications of Thiazole Orange in Fluorescent Sensing of Biomolecules and Ions.  |  Suss, O., et al. 2021. Molecules. 26: PMID: 34068759
  9. Stacked Thiazole Orange Dyes in DNA Capable of Switching Emissive Behavior in Response to Structural Transitions.  |  Takada, T., et al. 2021. Chembiochem. 22: 2729-2735. PMID: 34191388
  10. Ultrafast Excited-State Dynamics of Thiazole Orange.  |  Zhao, Z., et al. 2022. Chem Phys. 553: PMID: 35465176

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Thiazole orange, 250 mg

sc-215967
250 mg
$98.00

Thiazole orange, 1 g

sc-215967A
1 g
$252.00

Hi, we use Thiazole orange to stain our agarose gels to check DNA in a transilluminator. Which wavelength should we select (254 nm or 312)? Thanks

Asked by: JaneP
Thank you for your question. For Thiazole orange, Ex/Em: 512/533 (nm).
Answered by: Technical Support
Date published: 2019-05-17

Hi, orange thiazole is properly to be used in flow citometry? Can you send mi to Argentina?

Asked by: fuad
Thank you for your question. We do not have a protocol for using this chemical for flow cytometry, however, there is a publication which may be a useful reference for more information. Please see PMID: 2591157 . Please contact our authorized distributor in Argentina for information about product availability and shipping lead times. https://www.scbt.com/scbt/resources/distributors
Answered by: Technical Support
Date published: 2018-11-22
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Rated 5 out of 5 by from Various publications cite the use of ThiazoleVarious publications cite the use of Thiazole orange, a fluorescent dye DNA stain, for reticulocyte analysis. Also potentially useful for Plasmodium species analysis. -SCBT Publication Review
Date published: 2015-06-14
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Thiazole orange is rated 5.0 out of 5 by 1.
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