Thiamphenicol Glycinate hydrochloride (CAS 2611-61-2)

Thiamphenicol glycinate hydrochloride is a glycinate ester derivative of thiamphenicol, which itself is a methyl-sulfonyl analogue of chloramphenicol, and is employed primarily for its bacteriostatic effects in research settings. The compound functions by targeting the bacterial ribosome, specifically binding to the 50S subunit, which is crucial for protein synthesis. By attaching to this subunit, thiamphenicol glycinate hydrochloride inhibits peptidyl transferase activity, effectively blocking the peptide bond formation that is essential for linking amino acids during the translation process. This interruption halts bacterial protein synthesis, thereby impeding bacterial growth. In scientific research, thiamphenicol glycinate hydrochloride is utilized to investigate the mechanisms of action of bacteriostatic agents and their specific interactions with ribosomal components. Its role in inhibiting protein synthesis makes it a useful tool for studying ribosomal function and the effects of modifications on ribosomal resistance to antibiotics. Additionally, this compound assists in understanding how structural changes in antibiotics influence their efficacy and the development of resistance mechanisms in bacteria. Research involving thiamphenicol glycinate hydrochloride contributes to broader insights into microbial physiology and the underlying molecular basis of action of synthetic antibacterial agents.