Thiamine pyrophosphate (CAS 154-87-0)
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Thiamine pyrophosphate (TPP), also known as thiamine diphosphate, is the active form of thiamine (vitamin B1). It serves as an essential cofactor for several enzymes that are crucial for carbohydrate metabolism. TPP plays a vital role in enzymatic processes that convert sugars into energy within cells, particularly in the Krebs cycle and the pentose phosphate pathway. The compound acts primarily by facilitating the decarboxylation of alpha-keto acids and the transfer of hydroxyalkyl groups. This function is critical in several key enzymes, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, which are involved in the metabolic pathways that convert nutrients into energy and are essential for cellular respiration. Due to its role in energy metabolism, TPP is crucial for the proper function of the nervous system, heart, and muscles.
Thiamine pyrophosphate (CAS 154-87-0) References
- Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches. | Cressina, E., et al. 2011. Biochem Soc Trans. 39: 652-7. PMID: 21428956
- Thiamine pyrophosphate uptake into isolated rat liver mitochondria. | Barile, M., et al. 1990. Arch Biochem Biophys. 280: 352-7. PMID: 2369127
- Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney. | Altuner, D., et al. 2013. Indian J Pharmacol. 45: 339-43. PMID: 24014907
- The role of thiamine pyrophosphate in prevention of cisplatin ototoxicity in an animal model. | Kuduban, O., et al. 2013. ScientificWorldJournal. 2013: 182694. PMID: 24163613
- The protective effect of thiamine pyrophosphate, but not thiamine, against cardiotoxicity induced with cisplatin in rats. | Coskun, R., et al. 2014. Drug Chem Toxicol. 37: 290-4. PMID: 24215635
- Thiamine pyrophosphate stimulates acetone activation by Desulfococcus biacutus as monitored by a fluorogenic ATP analogue. | Gutiérrez Acosta, OB., et al. 2014. ACS Chem Biol. 9: 1263-6. PMID: 24779857
- Examination of the effects of thiamine and thiamine pyrophosphate on Doxorubicin-induced experimental cardiotoxicity. | Polat, B., et al. 2015. J Cardiovasc Pharmacol Ther. 20: 221-9. PMID: 25316705
- The effects of thiamine and thiamine pyrophosphate on alcohol-induced hepatic damage biomarkers in rats. | Yilmaz, I., et al. 2015. Eur Rev Med Pharmacol Sci. 19: 664-70. PMID: 25753885
- The effect of thiamine pyrophosphate on ethambutol-induced ocular toxicity. | Cinici, E., et al. 2016. Cutan Ocul Toxicol. 35: 222-7. PMID: 26339826
- The effects of thiamine pyrophosphate on ethanol induced optic nerve damage. | Ucak, T., et al. 2019. BMC Pharmacol Toxicol. 20: 40. PMID: 31277705
- Mitochondrial transport and metabolism of the vitamin B-derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD+ , and related diseases: A review. | Palmieri, F., et al. 2022. IUBMB Life. 74: 592-617. PMID: 35304818
- Inhibition of thiamine pyrophosphate utilization by thiamine or its monophosphate in Escherichia coli. | Nakayama, H. and Hayashi, R. 1974. J Bacteriol. 118: 32-40. PMID: 4595201
- Thiamine pyrophosphate (cocarboxylase) as a growth factor for Haemophilus somnus. | Asmussen, MD. and Baugh, CL. 1981. J Clin Microbiol. 14: 178-83. PMID: 7276148
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiamine pyrophosphate, 1 g | sc-215966 | 1 g | $32.00 | |||
Thiamine pyrophosphate, 5 g | sc-215966A | 5 g | $95.00 | |||
Thiamine pyrophosphate, 25 g | sc-215966B | 25 g | $284.00 | |||
Thiamine pyrophosphate, 100 g | sc-215966C | 100 g | $1126.00 | |||
Thiamine pyrophosphate, 1 kg | sc-215966D | 1 kg | $5906.00 |