Molecular structure of TFAP, CAS Number: 1011244-68-0
TFAP (CAS 1011244-68-0)
Alternate Names:
N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide
Application:
TFAP is a selective inhibitor of Cox-1
CAS Number:
1011244-68-0
Purity:
≥97%
Molecular Weight:
281.23
Molecular Formula:
C13H10F3N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a Cox-1 (IC50 of 0.80 µM) selective inhibitor versus Cox-2 (IC50 of 210 µM) by targeting the enzyme′s active site and displays analgesic properties in mice and rats in vivo (30 mg/kg, p.o.) without long-term cytotoxic effects (300 mg/kg in mice, daily, p.o. for 14 days). Unlike Cox-2-inhibiting analgesics such as aspirin, TFAP is shown not to cause gastric damage in rats in vivo (300 mg/kg, p.o.).
TFAP (CAS 1011244-68-0) References
- Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. | Kakuta, H., et al. 2008. J Med Chem. 51: 2400-11. PMID: 18363350
- Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor. | Kakuta, H., et al. 2010. Bioorg Med Chem Lett. 20: 1840-3. PMID: 20185310
- Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking. | Carlile, GW., et al. 2015. J Cyst Fibros. 14: 16-25. PMID: 24974227
- IL-1β reduces tonic contraction of mesenteric lymphatic muscle cells, with the involvement of cycloxygenase-2 and prostaglandin E2. | Al-Kofahi, M., et al. 2015. Br J Pharmacol. 172: 4038-51. PMID: 25989136
- COX-1 Inhibitors: Beyond Structure Toward Therapy. | Vitale, P., et al. 2016. Med Res Rev. 36: 641-71. PMID: 27111555
- Radioiodinated indomethacin amide for molecular imaging of cyclooxygenase-2 expressing tumors. | Morgenroth, A., et al. 2017. Oncotarget. 8: 18059-18069. PMID: 28407689
- IL-1β reduces cardiac lymphatic muscle contraction via COX-2 and PGE2 induction: Potential role in myocarditis. | Al-Kofahi, M., et al. 2018. Biomed Pharmacother. 107: 1591-1600. PMID: 30257377
Inhibitor of:
Cox.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFAP, 10 mg | sc-364633 | 10 mg | $194.00 |