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Tetrazole solution (CAS 288-94-8)

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Alternate Names:
2H-tetrazole
Application:
Tetrazole solution is a catalyst for phosphoramidite synthesis
CAS Number:
288-94-8
Purity:
≥99%
Molecular Weight:
70.05
Molecular Formula:
CH2N4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetrazole is an organic compound characterized by a five-membered ring containing four nitrogen atoms and one carbon atom, making it a highly energetic and reactive heterocyclic compound. In research, tetrazole and its derivatives are primarily utilized due to their capacity to act as bioisosteres for carboxylic acid groups, which makes them particularly valuable in the synthesis of more complex organic molecules. The mechanisms underlying their reactivity include the ability to release nitrogen gas rapidly upon decomposition, a property leveraged in materials science and energetic materials research. Tetrazole compounds are also known for their role in click chemistry, specifically in [3+2] cycloaddition reactions, which are essential for creating densely functionalized and structurally diverse molecules efficiently and selectively.


Tetrazole solution (CAS 288-94-8) References

  1. Recent progress in biological activities of synthesized phenothiazines.  |  Pluta, K., et al. 2011. Eur J Med Chem. 46: 3179-89. PMID: 21620536
  2. The synthesis of oligonucleotides containing an aliphatic amino group at the 5' terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis.  |  Smith, LM., et al. 1985. Nucleic Acids Res. 13: 2399-412. PMID: 4000959
  3. In situ activation of bis-dialkylaminophosphines--a new method for synthesizing deoxyoligonucleotides on polymer supports.  |  Barone, AD., et al. 1984. Nucleic Acids Res. 12: 4051-61. PMID: 6728676
  4. A simple preparation of 5′-o-dimethoxytrityl deoxyribonucleoside 3′-o-phosphorbisdiethylamidites as useful intermediates in the synthesis of oligodeoxyribonucleotides and their phosphorodiethylamidate analogs on a solid support  |  Yamana, Kazushige, et al. 1989. Tetrahedron. 45: 4135-4140.
  5. Large scale synthesis of oligoribonucleotides on PEG by the phosphite triester approach  |  Xu, Zu‐Sheng, Zai‐Wan Yang, and Yu Wang. 1995. Chinese Journal of Chemistry. 13: 246-250.
  6. Syntheses and structures of metal tetrazole coordination polymers†  |  Zhang, Xian-Ming, et al. 2006. Dalton Transactions. 26: 3170-3178.
  7. Solution-Phase Synthesis of Branched Oligonucleotides with up to 32 Nucleotides and the Reversible Formation of Materials  |  Schwenger, Alexander, Nicholas Birchall, and Clemens Richert. 2017. European Journal of Organic Chemistry. 2017: 5852-5864.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetrazole solution, 100 ml

sc-255654
100 ml
$175.00