Molecular structure of tetranor-PGEM, CAS Number: 24769-56-0
tetranor-PGEM (CAS 24769-56-0)
Application:
tetranor-PGEM is a marker for PGE2 biosynthesis
CAS Number:
24769-56-0
Molecular Weight:
328.36
Molecular Formula:
C16H24O7
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The major urinary metabolite of PGE1 and PGE2, and is used as a urinary marker of PGE2 biosynthesis.1,2 Approximately 15% of an infused dose of PGE2 appears as this metabolite in the urine of humans. Normal healthy males excrete 7-40 µg of tetranor-PGEM over a 24-hour period.1
tetranor-PGEM (CAS 24769-56-0) References
- Quantification of urinary PGEm, 6-keto PGF(1alpha) and 2,3-dinor-6-keto PGF(1alpha) by UFLC-MS/MS before and after exercise. | Blatnik, M. and Steenwyk, RC. 2010. Prostaglandins Other Lipid Mediat. 93: 8-13. PMID: 20416393
- Targeted eicosanoids lipidomics of exhaled breath condensate in healthy subjects. | Sanak, M., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 1796-800. PMID: 20627827
- Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers. | Zhang, Y., et al. 2011. J Mass Spectrom. 46: 705-11. PMID: 21706677
- Evaluation of urinary prostaglandin E2 metabolite as a biomarker in infants with fever due to viral infection. | Idborg, H., et al. 2014. Prostaglandins Leukot Essent Fatty Acids. 91: 269-75. PMID: 25305792
- Prostaglandin E2 and phagocytosis of inhaled particulate matter by airway macrophages in cystic fibrosis. | Liu, NM., et al. 2021. J Cyst Fibros. 20: 673-677. PMID: 33250436
- Development of Monoclonal Antibody-Based EIA for Tetranor-PGDM which Reflects PGD2 Production in the Body. | Nagata, N., et al. 2021. J Immunol Res. 2021: 5591115. PMID: 33997056
- Modulations of urinary lipid mediators in acute bladder cystitis. | Sugimoto, N., et al. 2023. Prostaglandins Other Lipid Mediat. 164: 106690. PMID: 36332874
- Elevated Prostaglandin E2 Synthesis Is Associated with Clinical and Radiological Disease Severity in Cystic Fibrosis. | Gartner, S., et al. 2024. J Clin Med. 13: PMID: 38610815
- Inhibition of prostaglandin synthesis in man. | Hamberg, M. 1972. Biochem Biophys Res Commun. 49: 720-6. PMID: 4638751
- Influence of adjuvant arthritis on main urinary metabolites of prostaglandin F and E in rats. | Honda, H., et al. 1980. Prostaglandins. 19: 259-69. PMID: 7384541
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
tetranor-PGEM, 25 µg | sc-222350 | 25 µg | $162.00 | |||
tetranor-PGEM, 50 µg | sc-222350A | 50 µg | $310.00 | |||
tetranor-PGEM, 100 µg | sc-222350B | 100 µg | $583.00 |