Molecular structure of tetranor-12(S)-HETE, CAS Number: 121842-79-3
tetranor-12(S)-HETE (CAS 121842-79-3)
Application:
tetranor-12(S)-HETE is a derivative of 12(S)-HETE
CAS Number:
121842-79-3
Molecular Weight:
266.37
Molecular Formula:
C16H26O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Product of arachidonic acid metabolism via the 12-lipoxygenase pathway. Found primarily in platelets, leukocytes, smooth muscle cells, to a lesser extent.1 Enhances adhesion of tumor cells to endothelial cells, fibronectin, and the subendothelial matrix.2 The major b-oxidation product resulting from the peroxisome metabolism of 12(S)-HETE in numerous tissues and Lewis lung carcinoma cells.3,4 Though no biological function has yet been gleaned for this product, some data give an indication to it′s role in controlling the inflammatory response in injured corneas.
tetranor-12(S)-HETE (CAS 121842-79-3) References
- Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. | Grossi, IM., et al. 1989. Cancer Res. 49: 1029-37. PMID: 2492204
- Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid. | Setkowicz, M., et al. 2015. Br J Dermatol. 172: 337-44. PMID: 24975552
- Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages. | Kriska, T., et al. 2018. J Lipid Res. 59: 615-624. PMID: 29472381
- Activation of leukocyte movement and displacement of [3H]leukotriene B4 from leukocyte membrane preparations by (12R)- and (12S)-hydroxyeicosatetraenoic acid. | Evans, JF., et al. 1987. Biochim Biophys Acta. 917: 406-10. PMID: 3026490
- Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma. | Heiling, S., et al. 2021. Metabolites. 11: PMID: 34564454
- Serum Oxylipin Profiles Identify Potential Biomarkers in Patients with Acute Aortic Dissection. | Jiang, Y., et al. 2022. Metabolites. 12: PMID: 35888709
- Heat-moisture treatment enhances the ordered degree of starch structure in whole chestnut flour and alters its gut microbiota modulation in mice fed with high-fat diet. | Guo, Q., et al. 2024. Int J Biol Macromol. 254: 127961. PMID: 37951440
- Eicosanoids and Oxylipin Signature in Hereditary Hemochromatosis Patients Are Similar to Dysmetabolic Iron Overload Syndrome Patients but Are Impacted by Dietary Iron Absorption. | Lobbes, H., et al. 2024. Ann Nutr Metab. 80: 117-127. PMID: 38354712
- The incorporation and release of 12(S)-hydroxyeicosatetraenoic acid and its major metabolite, 8(S)-hydroxyhexadecatrienoic acid, from rabbit corneal lipids. | Hurst, JS., et al. 1994. Exp Eye Res. 59: 97-105. PMID: 7835402
- Metabolism of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid by kidney and liver peroxisomes. | Wigren, J., et al. 1993. J Lipid Res. 34: 625-31. PMID: 8496668
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
tetranor-12(S)-HETE, 25 µg | sc-205521 | 25 µg | $155.00 | |||
tetranor-12(S)-HETE, 100 µg | sc-205521A | 100 µg | $555.00 |