tetranectin Antibody (F-8): sc-376940

tetranectin Antibody (F-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects tetranectin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-tetranectin antibody (F-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. tetranectin is a homotrimeric glycoprotein that plays a crucial role in tissue remodeling and the regulation of proteolytic processes, primarily through its ability to bind calcium, heparin, and plasminogen kringle 4. tetranectin is predominantly located in the extracellular matrix (ECM) of certain carcinomas, where tetranectin is absent in normal tissues, highlighting tetranectin′s significance in cancer biology. tetranectin presence in the ECM is associated with extracellular proteolysis, a key factor that enables malignant cells to invade normal tissues and metastasize. Notably, decreased levels of plasma tetranectin or increased concentrations in the stroma of tumors correlate with cancer progression and poor prognosis. Additionally, tetranectin may influence tumor growth by modulating the activities of plasminogen and its fragment, angiostatin, which is known to inhibit tumor cell proliferation.

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tetranectin Antibody (F-8) References:

1. Serum levels of tetranectin, intercellular adhesion molecule-1 and interleukin-10 in B-chronic lymphocytic leukemia.  |  Kamper, EF., et al. 1999. Clin Biochem. 32: 639-45. PMID: 10638947
2. The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain.  |  Lorentsen, RH., et al. 2000. Biochem J. 347 Pt 1: 83-7. PMID: 10727405
3. Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL.  |  Caterer, NR., et al. 2002. Biol Chem. 383: 1743-50. PMID: 12530539
4. Structure of the plasminogen kringle 4 binding calcium-free form of the C-type lectin-like domain of tetranectin.  |  Nielbo, S., et al. 2004. Biochemistry. 43: 8636-43. PMID: 15236571
5. In the search of potential human islet stem cells: is tetranectin showing us the way?  |  Hermann, M., et al. 2005. Transplant Proc. 37: 1322-5. PMID: 15848710
6. Tetranectin in cerebrospinal fluid: biochemical characterisation and evidence of intrathecal synthesis or selective uptake into CSF.  |  Stoevring, B., et al. 2005. Clin Chim Acta. 359: 65-71. PMID: 15901484
7. Tetranectin, a trimeric plasminogen-binding C-type lectin.  |  Holtet, TL., et al. 1997. Protein Sci. 6: 1511-5. PMID: 9232652
8. Determination of serum tetranectin: technical and clinical evaluation of three sandwich immunoassays.  |  Thougaard, AV., et al. 1998. Clin Chim Acta. 276: 19-34. PMID: 9760017
9. Human tetranectin: methodological and clinical studies.  |  Høgdall, CK. 1998. APMIS Suppl. 86: 1-31. PMID: 9868384

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-tetranectin Antibody (F-8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-tetranectin Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

tetranectin Antibody (F-8) Specifications

Alternate Product Name: tetranectin

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 103-202

Epitope Target: tetranectin

Epitope Species: human

Product Reactivity/Detection: tetranectin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for tetranectin Antibody (F-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin