Date published: 2025-12-15

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Tetrahydropalmatine hydrochloride (CAS 6024-85-7)

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Alternate Names:
(D,L)-Tetrahydropalmatine hydrochloride
CAS Number:
6024-85-7
Molecular Weight:
391.5
Molecular Formula:
C21H26ClNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Voltage-dependent Ca2+ channel inhibitor. Berberis diisoquinoline alkaloid; a D1/D2 Dopaminergic receptor antagonist presenting analgesic and sedative/tranquillizing effects.


Tetrahydropalmatine hydrochloride (CAS 6024-85-7) References

  1. Impact of Tetrahydropalmatine on the Pharmacokinetics of Probe Drugs for CYP1A2, 2D6 and 3A Isoenzymes in Beagle Dogs.  |  Zhao, Y., et al. 2016. Phytother Res. 30: 906-14. PMID: 26990021
  2. [Effects of dl-tetrahydropalmatine on contractions of rabbit aorta strips].  |  Zhao, DK., et al. 1988. Zhongguo Yao Li Xue Bao. 9: 153-5. PMID: 3188953
  3. Tetrahydropalmatine triggers angiogenesis via regulation of arginine biosynthesis.  |  Cui, H., et al. 2021. Pharmacol Res. 163: 105242. PMID: 33075491
  4. Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.  |  Liu, L., et al. 2021. ACS Chem Neurosci. 12: 3373-3386. PMID: 34448569
  5. Tetrahydropalmatine attenuates MSU crystal-induced gouty arthritis by inhibiting ROS-mediated NLRP3 inflammasome activation.  |  Wang, Y., et al. 2021. Int Immunopharmacol. 100: 108107. PMID: 34482265
  6. A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine.  |  Du, Q., et al. 2022. Front Pharmacol. 13: 890078. PMID: 35559252
  7. Cardioprotective Effects of Tetrahydropalmatine on Acute Myocardial Infarction in Rats.  |  Han, BJ., et al. 2022. Am J Chin Med. 50: 1887-1904. PMID: 36056468
  8. Tetrahydropalmatine ameliorates hepatic steatosis in nonalcoholic fatty liver disease by switching lipid metabolism via AMPK-SREBP-1c-Sirt1 signaling axis.  |  Yin, X., et al. 2023. Phytomedicine. 119: 155005. PMID: 37562090
  9. Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.  |  Chen, X., et al. 2023. Biomed Pharmacother. 169: 115887. PMID: 37984303
  10. Tetrahydropalmatine promotes random skin flap survival in rats via the PI3K/AKT signaling pathway.  |  Yang, J., et al. 2024. J Ethnopharmacol. 324: 117808. PMID: 38280663

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetrahydropalmatine hydrochloride, 1 mg

sc-296504
1 mg
$160.00