Molecular structure of Tetrahydrofolic acid, CAS Number: 135-16-0
Tetrahydrofolic acid
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolic acid metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids. A recent use of Tetrahydrofolic acid (THF) is for the studying the activation of riboswitches.
Tetrahydrofolic acid References
- Tetrahydrofolic acid: an inhibitor of the methyltetrahydrofolic acid-mediated methylation of indolethylamines. | Lin, RL. and Narasimhachari, N. 1975. Biochim Biophys Acta. 385: 268-74. PMID: 1055009
- On the occurrence of N10-formyltetrahydrofolic acid by enzymic formylation of tetrahydrofolic acid and on the mechanism of this reaction. | GREENBERG, GR., et al. 1955. Biochim Biophys Acta. 17: 589-91. PMID: 13250013
- The transfer of the formimino group of formamidinoglutaric acid to tetrahydrofolic acid. | MILLER, A. and WAELSCH, H. 1956. Arch Biochem Biophys. 63: 263-6. PMID: 13341067
- Formimino transfer from formamidinoglutaric acid to tetrahydrofolic acid. | MILLER, A. and WAELSCH, H. 1957. J Biol Chem. 228: 397-417. PMID: 13475327
- Enzymatic reduction of folic acid and dihydrofolic acid to tetrahydrofolic acid. | FUTTERMAN, S. 1957. J Biol Chem. 228: 1031-8. PMID: 13475378
- Interaction of formaldehyde and tetrahydrofolic acid and its relation to the enzymic synthesis of serine. | BLAKLEY, RL. 1958. Nature. 182: 1719-22. PMID: 13622630
- Enzymic conversion of tetrahydrofolic acid to folinic acid by plant protein. | BYERS, EH., et al. 1961. Nature. 191: 179-80. PMID: 13689562
- Tetrahydrofolic acid as the principal congener of plasma folates in pigs. | Natsuhori, M., et al. 1991. Am J Physiol. 261: R82-6. PMID: 1858958
- Assessment of Folic Acid Supplementation in Pregnant Women by Estimation of Serum Levels of Tetrahydrofolic Acid, Dihydrofolate Reductase, and Homocysteine. | Naithani, M., et al. 2016. Scientifica (Cairo). 2016: 1520685. PMID: 27064332
- Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells. | García-Calderón, CB., et al. 2018. Cell Death Differ. 25: 1967-1979. PMID: 29511342
- The Second Class of Tetrahydrofolate (THF-II) Riboswitches Recognizes the Tetrahydrofolic Acid Ligand via Local Conformation Changes. | Zhang, M., et al. 2022. Int J Mol Sci. 23: PMID: 35682583
- The mechanism of the condensation of formaldehyde with tetrahydrofolic acid. | Kallen, RG. and Jencks, WP. 1966. J Biol Chem. 241: 5851-63. PMID: 5954363
Activator of:
ALDH1L2, CPF, Formate Dehydrogenase, FTCD, GCH-I, RAI1, and ZNF816A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tetrahydrofolic acid, 25 mg | sc-215955 | 25 mg | $78.00 | |||
Tetrahydrofolic acid, 100 mg | sc-215955A | 100 mg | $226.00 | |||
Tetrahydrofolic acid, 1 g | sc-215955B | 1 g | $944.00 |