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Tetrahydrocortisol (CAS 53-02-1)

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Alternate Names:
Tetrahydrocortisol is also known as Urocortisol.
Application:
Tetrahydrocortisol is a metabolite of cortisol.
CAS Number:
53-02-1
Molecular Weight:
366.49
Molecular Formula:
C21H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetrahydrocortisol, classified as a steroid, emerges as a pivotal metabolite of cortisol, intricately involved in response mechanisms to stress and metabolic processes, primarily synthesized by lymphocytes. Its production and role extend into the fascinating realm of research, especially in the study of the endocrine system′s regulatory functions and the intricate interplay between stress responses and immune function. Researchers delve into its mechanism of action to understand how it influences the body′s homeostasis, particularly focusing on its ability to modulate immune responses and metabolic pathways. This metabolite′s significance is underscored in studies aimed at elucidating the biochemical cascades that govern physiological stress responses and metabolic equilibrium, providing a window into the complex biochemical network that maintains health and stability within the organism.


Tetrahydrocortisol (CAS 53-02-1) References

  1. Tetrahydrocortisol/tetrahydrocortisone ratio (H4F/H4E) as an indicator of depressive feelings.  |  Persky, H. 1976. Psychosom Med. 38: 13-8. PMID: 1257380
  2. [Retinal toxicity of intravitreally injected steroids on the rabbit eye].  |  Kamei, M., et al. 1992. Nippon Ganka Gakkai Zasshi. 96: 1253-60. PMID: 1442349
  3. Tetrahydrocortisol-apolipoprotein A-I complex specifically interacts with eukaryotic DNA and GCC elements of genes.  |  Panin, LE., et al. 2003. J Steroid Biochem Mol Biol. 87: 309-18. PMID: 14698212
  4. Simultaneous determination of tetrahydrocortisol, allotetrahydrocortisol and tetrahydrocortisone in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry.  |  Yamashita, K., et al. 2008. Steroids. 73: 727-37. PMID: 18394666
  5. Effect of complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone on protein biosynthesis in rat hepatocytes culture.  |  Panin, LE., et al. 2007. Bull Exp Biol Med. 144: 291-3. PMID: 18457017
  6. [Mechanisms of interaction of tetrahydrocortisol and its complex with apolipoprotein A-I and DNA regulatory cis-elements of CC(GCC)5/GG(CGG)5 type].  |  Panin, LE., et al. 2008. Biofizika. 53: 42-7. PMID: 18488499
  7. Urine ratio of tetrahydrocortisol to tetrahydrodeoxycortisol to screen for the systemic administration of cortisone and hydrocortisone.  |  Meklat, N., et al. 2009. Forensic Sci Int. 185: e13-7. PMID: 19185436
  8. LC-MS/MS Method for the Simultaneous Determination of Free Urinary Steroids.  |  Allende, F., et al. 2014. Chromatographia. 77: 637-642. PMID: 24683202
  9. Subcellular distribution of 3H--hydrocortisone and its metabolites in the liver and kidneys of normal and alloxan diabetic rats.  |  Minchenko, AG. and Tronjko, ND. 1988. Endocrinol Exp. 22: 19-28. PMID: 3259502
  10. Determination of cortisol, tetrahydrocortisol, tetrahydrocortisone, corticosterone, and aldosterone in human amniotic fluid.  |  Aderjan, R., et al. 1977. J Steroid Biochem. 8: 525-8. PMID: 599923
  11. Response of the FSaII fibrosarcoma to antiangiogenic modulators plus cytotoxic agents.  |  Teicher, BA., et al. 1993. Anticancer Res. 13: 2101-6. PMID: 7507654
  12. beta-cyclodextrin tetradecasulfate/tetrahydrocortisol +/- minocycline as modulators of cancer therapies in vitro and in vivo against primary and metastatic Lewis lung carcinoma.  |  Teicher, BA., et al. 1993. Cancer Chemother Pharmacol. 33: 229-38. PMID: 8269604
  13. Effects of cortisol and tetrahydrocortisol on the cloned fibroblast derived from rat carrageenin granuloma.  |  Murota, SI., et al. 1976. Biochem Pharmacol. 25: 1107-13. PMID: 944583
  14. Simultaneous determination of tetrahydrocortisol and tetrahydrocortisone in human plasma and urine by stable isotope dilution mass spectrometry.  |  Furuta, T., et al. 1998. J Chromatogr B Biomed Sci Appl. 706: 181-90. PMID: 9551804

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetrahydrocortisol, 10 mg

sc-472832
10 mg
$406.00

Tetrahydrocortisol, 100 mg

sc-472832A
100 mg
$2968.00