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Tetrafluorophthalic acid (CAS 652-03-9)

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Alternate Names:
3,4,5,6-Tetrafluorophthalic acid
CAS Number:
652-03-9
Molecular Weight:
238.09
Molecular Formula:
C8H2F4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetrafluorophthalic acid has potential applications across a spectrum of scientific investigations, such as organic synthesis, catalysis, and electronics. This compound is a building block in the synthesis of fluorinated aromatic compounds, which have their own properties that are of interest in the materials science field. It is also used as a catalyst in a diverse array of organic reactions, spanning oxidation, hydrogenation, and coupling processes Tetrafluorophthalic acid finds application as an intermediate in the intricate synthesis of polyfluorinated biphenyls, which are used as liquid crystal displays.


Tetrafluorophthalic acid (CAS 652-03-9) References

  1. 9,10-Dichlorooctafluoroanthracene as a building block for n-type organic semiconductors.  |  Tannaci, JF., et al. 2007. J Org Chem. 72: 5567-73. PMID: 17590045
  2. The effects of oral treatment with transfluthrin on the urothelium of rats and its metabolite, tetrafluorobenzoic acid on urothelial cells in vitro.  |  Yokohira, M., et al. 2011. Food Chem Toxicol. 49: 1215-23. PMID: 21377505
  3. Preformulation study of Nsc-726796.  |  Guo, D., et al. 2012. AAPS PharmSciTech. 13: 661-73. PMID: 22552929
  4. Effect of the Modifier Structure on the Performance of Barium Titanate/Poly(vinylidene fluoride) Nanocomposites for Energy Storage Applications.  |  Niu, Y., et al. 2015. ACS Appl Mater Interfaces. 7: 24168-76. PMID: 26457611
  5. Temperature-induced 1D lanthanide polymeric frameworks based on Ln(n) (n = 2, 2, 4, 6) cores: synthesis, crystal structures and luminescence properties.  |  Li, JJ., et al. 2016. Dalton Trans. 45: 2924-35. PMID: 26750861
  6. Strontium-coordination polymers based on tetrafluorophthalic and phthalic acids: mechanochemical synthesis, ab initio structures determination, and spectroscopic characterization.  |  Al-Terkawi, AA., et al. 2017. Dalton Trans. 46: 12574-12587. PMID: 28906520
  7. Ca-Tetrafluorophthalate and Sr-isophthalate: mechanochemical synthesis and characterization in comparison with other Ca-and Sr-coordination polymers.  |  Al-Terkawi, AA., et al. 2018. Dalton Trans. 47: 5743-5754. PMID: 29634064
  8. Study of the decarboxylation mechanism of fluorobenzoic acids by strong N-bases  |  Błażej Gierczyk, Grzegorz Wojciechowski, Bogumił Brzezinski, Eugeniusz Grech, Grzegorz Schroeder. 2001. 14: 691-696.
  9. Preparation and tribological properties of tetrafluorobenzoic acid-modified TiO2 nanoparticles as lubricant additives  |  Wenyu Ye, Tiefeng Cheng, Qing Ye, Xinyong Guo, Zhijun Zhang, Hongxin Dang. 2003. Materials Science and Engineering: A. 359: 82-85.
  10. Synthesis and Biological Activity of Substituted Tetrachlorophthalic Acid Monoamides  |  A. V. Dolzhenko, N. V. Kolotova, V. P. Kotegov, B. Ya. Syropyatov, M. V. Vasilyuk, G. V. Rudakova, V. V. Novikova & V. P. Feshin. 2005. Pharmaceutical Chemistry Journal. 39: 409–412.
  11. Structural characterization of two salts derived from tetrafluorophthalic acid and isopropylamine  |  Markus Pietsch a, Hans-Georg Häcker a, Gregor Schnakenburg b, Wilfried Hoffbauer b, Martin Nieger c, Michael Gütschow a. 2008. Journal of Molecular Structure. 878: 131-138.
  12. Using halogen⋯halogen interactions or C/N–H⋯Cl hydrogen bonding to direct crystal packing in tetrachlorophthalic acid with N-heterocyclic compounds  |  Yanjing Hu, Zhiqiang Li, Yiran Zhao, Yu Yang*, Faqian Liu and Lei Wang*. 2015. RSC Adv. 5: 10275-10289.
  13. Intermolecular hydrogen bonding, structural and vibrational assignments of 2, 3, 4, 5-tetrafluorobenzoic acid using density functional theory  |  G. Subhapriya a, S. Kalyanaraman a, N. Surumbarkuzhali b, S. Vijayalakshmi a, V. Krishnakumar c, S. Gandhimathi d. 2017. Journal of Molecular Structure. 1128: 534-543.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetrafluorophthalic acid, 5 g

sc-258225
5 g
$91.00