Date published: 2025-10-2

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Tetraethylene glycol monohexadecyl ether (CAS 5274-63-5)

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Alternate Names:
C16E4, Hexadecyl tetraethylene glycol ether, Hexadecyltetraglycol
Application:
Tetraethylene glycol monohexadecyl ether is a surfactant used in gel-emulsion preparation
CAS Number:
5274-63-5
Molecular Weight:
418.65
Molecular Formula:
C24H50O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetraethylene glycol monohexadecyl ether, a chemical compound extensively studied in scientific research, holds significant importance and exhibits diverse applications in various research fields. Researchers have focused on understanding its mechanisms of action and exploring its potential in different areas of study. One notable application of tetraethylene glycol monohexadecyl ether is in the field of colloid and interface science. It acts as a nonionic surfactant, displaying remarkable emulsifying and solubilizing properties. The compound′s mechanism of action involves its ability to reduce the interfacial tension between immiscible substances, thereby promoting the formation and stabilization of emulsions. Tetraethylene glycol monohexadecyl ether has been utilized in research related to emulsion preparation, nanoparticle synthesis, and controlled release systems. Its surfactant properties have been particularly valuable in the formulation of emulsions, where it can enhance stability, uniformity, and control droplet size. Furthermore, this compound has found applications in the field of materials science, where it has been used as a surface modifier and dispersant to improve compatibility and processability of various materials. Tetraethylene glycol monohexadecyl ether′s ability to enhance solubility and dispersion has been harnessed to optimize material properties and performance. By harnessing the specific mechanisms and applications of tetraethylene glycol monohexadecyl ether, researchers continue to make significant strides in colloid and interface science, materials science, and related disciplines, offering valuable insights and advancements in scientific research.


Tetraethylene glycol monohexadecyl ether (CAS 5274-63-5) References

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  2. Rheological behavior of polyoxyethylene phytosterol-polyoxyethylene cholesterol/tetraethylene glycol monododecyl ether/water systems.  |  Sharma, SC., et al. 2010. J Oleo Sci. 59: 471-6. PMID: 20720377
  3. Characterization of mixed non-ionic surfactants n-octyl-β-D-thioglucoside and octaethylene-glycol monododecyl ether: micellization and microstructure.  |  Ruiz, CC. and Molina-Bolívar, JA. 2011. J Colloid Interface Sci. 361: 178-85. PMID: 21641607
  4. Multi-lamellar vesicle formation in a long-chain nonionic surfactant: C16E4/D2O system.  |  Gentile, L., et al. 2011. J Colloid Interface Sci. 362: 1-4. PMID: 21767850
  5. Structural transitions induced by shear flow and temperature variation in a nonionic surfactant/water system.  |  Gentile, L., et al. 2012. J Colloid Interface Sci. 372: 32-9. PMID: 22321990
  6. Phase Structure Transition and Properties of Salt-Free Phosphoric Acid/Non-ionic Surfactants in Water.  |  Wang, L., et al. 2016. Langmuir. 32: 8366-73. PMID: 27490998
  7. Metabolic changes of membrane lipid composition in Acholeplasma laidlawii by hydrocarbons, alcohols, and detergents: arguments for effects on lipid packing.  |  Wieslander, A., et al. 1986. Biochemistry. 25: 7511-7. PMID: 3801430
  8. Electrosorption of tetraethylene glycol monododecyl ether at the polarized nitrobenzene-water interface  |  Kakiuchi, T., Usui, T., & Senda, M. 1990. Bulletin of the Chemical Society of Japan. 63(7): 2044-2050.
  9. Influence of sodium dodecyl sulfate on structure and rheology of aqueous solutions of the nonionic surfactant tetraethyleneglycol-monododecyl ether (C12E4)  |  Nettesheim, F., Zipfel, J., Lindner, P., & Richtering, W. 2001. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 183: 563-574.
  10. Reverse Micelles and Protomicelles of Tetraethylene Glycol Monododecyl Ether in Systems with Heptane and Nile Red  |  Movchan, T. G., Rusanov, A. I., & Plotnikova, E. V. 2022. Russian Journal of General Chemistry. 92(4): 650-658.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetraethylene glycol monohexadecyl ether, 1 g

sc-281577
1 g
$300.00

Tetraethylene glycol monohexadecyl ether, 2.5 g

sc-281577A
2.5 g
$700.00