Molecular structure of Tetraethylammonium chloride, CAS Number: 56-34-8
Tetraethylammonium chloride (CAS 56-34-8)
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Alternate Names:
Etamon chloride; TEA Chloride
Application:
Tetraethylammonium chloride is a small molecule blocker of K+ channels
CAS Number:
56-34-8
Purity:
≥98%
Molecular Weight:
165.70
Molecular Formula:
C8H20ClN
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Tetraethylammonium chloride is widely used in the field of electrochemistry, particularly in the study of ion channel functions and membrane potentials. This compound serves as a tool in neuroscience research to understand nerve transmission processes by blocking potassium channels, which helps in analyzing the electrical activity of neurons. Additionally, Tetraethylammonium chloride is employed in the synthesis of ionic liquids, where it acts as a precursor for more complex quaternary ammonium salts. Its properties are exploited in electrochemical applications to improve the efficiency of electrolytes in various electrochemical cells and sensors. Researchers also explore Tetraethylammonium chloride in environmental science to develop better methods for water purification and desalination, leveraging its ionic nature to manipulate and study ion exchange processes.
Tetraethylammonium chloride (CAS 56-34-8) References
- Hyperpolarization-activated inward potassium and calcium-sensitive chloride currents in beating pacemaker insect neurosecretory cells (dorsal unpaired median neurons). | Raymond, V. and Lapied, B. 1999. Neuroscience. 93: 1207-18. PMID: 10473286
- Modulation by K+ channels of action potential-evoked intracellular Ca2+ concentration rises in rat cerebellar basket cell axons. | Tan, YP. and Llano, I. 1999. J Physiol. 520 Pt 1: 65-78. PMID: 10517801
- Action of tetraethylammonium chloride on neuromuscular transmission in frogs. | KOKETSU, K. 1958. Am J Physiol. 193: 213-8. PMID: 13521010
- ANOMALOUS RECTIFICATION IN THE SQUID GIANT AXON INJECTED WITH TETRAETHYLAMMONIUM CHLORIDE. | ARMSTRONG, CM. and BINSTOCK, L. 1965. J Gen Physiol. 48: 859-72. PMID: 14324992
- Tetraethylammonium chloride in the treatment of multiple sclerosis. | ARKIN, H., et al. 1950. AMA Arch Neurol Psychiatry. 64: 536-45. PMID: 14770597
- Acute myocardial infarction following tetraethylammonium chloride therapy. | LIVINGSTONE, DJ. 1950. Br Med J. 2: 713-4. PMID: 14772462
- Tetraethylammonium chloride in post-herpetic neuralgia. | WALLERSTEIN, R. 1949. Calif Med. 71: 421. PMID: 15397542
- Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. | Niu, LG., et al. 2008. Eur J Pharmacol. 580: 169-74. PMID: 17997400
- Tetraethylammonium chloride in experimental vascular injuries of limb, bowel and heart. | HILL, EJ. and HAMMER, JM. 1949. Arch Surg (1920). 59: 527-41. PMID: 18147734
- Tetraethylammonium chloride in treatment of herpes zoster and intercostal neuralgia. | FISHER, RL., et al. 1949. Arch Neurol Psychiatry. 61: 194-8. PMID: 18152784
- Experiences with tetraethylammonium chloride in hypertension. | LYONS, HH. and HOOBLER, SW. 1948. J Am Med Assoc. 136: 608-13. PMID: 18899127
- Early effects of tetraethylammonium chloride on the contractile properties of isolated rabbit basilar arteries. | Young, AR., et al. 1987. J Cereb Blood Flow Metab. 7: 237-47. PMID: 2435745
- Evaluation of the effect of tetraethylammonium bromide and chloride on the growth and development of terrestrial plants. | Pawłowska, B. and Biczak, R. 2016. Chemosphere. 149: 24-33. PMID: 26844662
- Inactivation of Native K Channels. | Kodirov, SA., et al. 2022. J Membr Biol. 255: 13-31. PMID: 34383081
- Tetraethylammonium chloride reduces anaesthetic-induced neurotoxicity in Caenorhabditis elegans and mice. | Jung, S., et al. 2022. Br J Anaesth. 128: 77-88. PMID: 34857359
- Consequences of axonal transport blockade by batrachotoxin on mammalian neuromuscular junction. II. Late pre- and postsynaptic changes. | Deshpande, SS., et al. 1981. Brain Res. 225: 115-29. PMID: 6170390
- Tetraethylammonium contains an impurity which alkalizes cytoplasm and reduce calcium buffering in neurons. | Zucker, RS. 1981. Brain Res. 208: 473-8. PMID: 6260296
- Effects of tetraethylammonium-chloride and divalent cations on the afterhyperpolarization following repetitive firing in leech neurons. | Yang, J. and Kleinhaus, AL. 1984. Brain Res. 311: 380-4. PMID: 6498493
- Effect of tetraethylammonium chloride on action potential in cardiac Purkinje fibers. | Ito, S. and Surawicz, B. 1981. Am J Physiol. 241: H139-44. PMID: 7270702
- Release of TEA blockade of maxi-K+ channels by isoproterenol. | Fan, SF., et al. 1994. Biochem Biophys Res Commun. 201: 24-9. PMID: 8198580
Inhibitor of:
AChR, AQP1, AQP12A, AQP3, AQP6, AQP7, Complexin-3, Complexin-4, FAM18B, KCNG3, KCNMB3, KCNT2, KCNV1, KCNV2, KIR7.1, KVβ.1, KV1.7, KV3.2, KV4.2, KV9.3, NKAIN4, Olfr31, Olfr358, OR6C68, TMEM38B, Trk1, UNC-80, Vmn2r68, and Vmn2r69.Activator of:
BC014805, KVβ.3, KV1.1, SV2B, and Syntaxin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tetraethylammonium chloride, 25 g | sc-202834 | 25 g | $44.00 |