Date published: 2026-4-4

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Tetraethyl orthosilicate (CAS 78-10-4)

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Alternate Names:
Orthosilicic acid tetraethyl ester; Silicon tetraethoxide; TEOS
Application:
Tetraethyl orthosilicate is a commonly used precursor to prepare xerogel & study of mixed-metal bioactive glasses
CAS Number:
78-10-4
Purity:
≥96%
Molecular Weight:
208.33
Molecular Formula:
Si(OC2H5)4
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetraethyl orthosilicate (TEOS) is extensively used in materials science research, particularly in the field of sol-gel chemistry. In the laboratory, it is a precursor for the production of silicon dioxide (silica) and silicate-based materials through hydrolysis and condensation reactions. This compound is fundamental in the synthesis of various forms of silica, including films, monoliths, and nanoparticles, which are studied for their potential applications in coatings, optics, and electronics. Moreover, Tetraethyl orthosilicate is employed in the fabrication of silica-based aerogels, which are lightweight materials with high surface area and porosity, making them suitable for insulation, catalysis, and adsorption studies. In addition to its use in creating inorganic networks, Tetraethyl orthosilicate is also used in the preparation of organic-inorganic hybrid materials, where it can be co-condensed with organic precursors to form novel composites with unique properties.


Tetraethyl orthosilicate (CAS 78-10-4) References

  1. A kinetic study of the effect of ultrasound power on the sonohydrolysis of tetraethyl orthosilicate.  |  Côrtes, AD., et al. 2007. Ultrason Sonochem. 14: 711-6. PMID: 17236803
  2. Organic-inorganic hybrid materials for efficient enantioseparation using cellulose 3,5-dimethylphenylcarbamate and tetraethyl orthosilicate.  |  Ikai, T., et al. 2008. Chem Asian J. 3: 1494-9. PMID: 18506867
  3. Electrical-sensitive nanoparticle composed of chitosan and tetraethyl orthosilicate for controlled drug release.  |  Liu, KH., et al. 2009. J Nanosci Nanotechnol. 9: 1198-203. PMID: 19441487
  4. Synthesis and characterization of hollow silica particles from tetraethyl orthosilicate and sodium silicate.  |  Kim, J., et al. 2013. J Nanosci Nanotechnol. 13: 2284-8. PMID: 23755680
  5. Bioinspired, cysteamine-catalyzed co-silicification of (1H, 1H, 2H, 2HPerfluorooctyl) triethoxysilane and tetraethyl orthosilicate: formation of superhydrophobic surfaces.  |  Park, JH., et al. 2014. Chem Asian J. 9: 764-8. PMID: 24730056
  6. Silica Xerogel Obtained by Ultrashort Laser Irradiation of Tetraethyl Orthosilicate.  |  Sansone, M., et al. 2017. Chemphyschem. 18: 1140-1145. PMID: 28141903
  7. Small Titanium-Based MOFs Prepared with the Introduction of Tetraethyl Orthosilicate and Their Potential for Use in Drug Delivery.  |  Xie, Y., et al. 2018. ACS Appl Mater Interfaces. 10: 13325-13332. PMID: 29617554
  8. Improving the Performance and Reproducibility of Inverted Planar Perovskite Solar Cells Using Tetraethyl Orthosilicate as the Antisolvent.  |  Wang, M., et al. 2019. ACS Appl Mater Interfaces. 11: 3909-3916. PMID: 30618236
  9. Tetraethyl Orthosilicate-Based Hydrogels for Drug Delivery-Effects of Their Nanoparticulate Structure on Release Properties.  |  Serban, BA., et al. 2020. Gels. 6: PMID: 33126579
  10. Polyamide/Chitosan/Tetraethyl Orthosilicate Electrospun Nanofibers for a Novel and Promising Drug Carrier.  |  Feng, ZY., et al. 2021. J Nanosci Nanotechnol. 21: 5912-5919. PMID: 34229786
  11. Design and assessment of an energy self-supply process producing tetraethyl orthosilicate using rice husk.  |  T H Nguyen, T., et al. 2022. Bioresour Technol. 344: 126188. PMID: 34710592
  12. Solution-Processed Silicon Doped Tin Oxide Thin Films and Thin-Film Transistors Based on Tetraethyl Orthosilicate.  |  He, Z., et al. 2022. Membranes (Basel). 12: PMID: 35736297
  13. Manufacturability of a Tetraethyl Orthosilicate-Based Hydrogel for Use as a Single Application Otitis Externa Therapeutic.  |  Barrett-Catton, E., et al. 2022. Pharmaceutics. 14: PMID: 36297460
  14. Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.  |  George, A. and Shrivastav, PS. 2023. Int J Biol Macromol. 229: 51-61. PMID: 36587636

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetraethyl orthosilicate, 25 ml

sc-253664
25 ml
$37.00