Date published: 2026-2-25

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Tetradecyl Phosphonate (CAS 4671-75-4)

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Alternate Names:
n-Tetradecylphosphonic acid; 1-Tetradecanephosphonic acid
Application:
Tetradecyl Phosphonate is a pan-antagonist of EDG-2, EDG-4, and EDG-7
CAS Number:
4671-75-4
Molecular Weight:
278.37
Molecular Formula:
C14H31O3P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetradecyl Phosphonate is a pan-antagonist of EDG-2, EDG-4, and EDG-7 (EDG-2, EDG-4, and EDG-7 receptors) with IC50 values for inhibition of EDG-induced calcium mobilization of 10 μM, 5.5 μM, and 3.1 μM, respectively. Tetradecyl Phosphonate is an inhibitor of Autotaxin.


Tetradecyl Phosphonate (CAS 4671-75-4) References

1 Tokumura, A., Majima, E., Kariya, Y., et al. Identification of human lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem 277(42) 39436-39442 (2002 Oct 18). 2 Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54 265-269 (2002). 3 Noguchi, K., Ishii, S., Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 278(28) 25600-25606 (2003). 4 McIntyre, T.M., Pontsler, A.V., Silva, A.R., et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist. Proc Natl Acad Sci USA 100(1) 131-136 (2003). 5 Durgam, G.G., Virag, T., Walker, M.D., et al. Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptors ligands, activators of PPARγ, and inhibitors of autotaxin. J Med Chem 48 4919-4930 (2005).

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetradecyl Phosphonate, 100 mg

sc-205519
100 mg
$24.00

Tetradecyl Phosphonate, 500 mg

sc-205519A
500 mg
$115.00