Molecular structure of Tetradecyl-phosphocholine, CAS Number: 77733-28-9
Tetradecyl-phosphocholine (CAS 77733-28-9)
Alternate Names:
Phosphocholine tetradecyl ester; MAPCHO-14; Fos-Choline-14
Application:
Tetradecyl-phosphocholine is a detergent for membrane protein solubilization
CAS Number:
77733-28-9
Purity:
≥99%
Molecular Weight:
379.51
Molecular Formula:
C19H42NO4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tetradecyl-phosphocholine is a structural analog of myristoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. It is an aliphatic phospholipid that is a major component of biological membranes and may act to increase the fluidity of the cell membrane. This lipid is often used as a detergent for membrane protein solubilization and purification. It has been also used as a helper lipid for in vitro gene transfer, and it may act to have some anticancer activity.
Tetradecyl-phosphocholine (CAS 77733-28-9) References
- Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence. | Watschinger, K., et al. 2009. Biol Chem. 390: 3-10. PMID: 19007315
- Optimized proteomic analysis of rat liver microsomes using dual enzyme digestion with 2D-LC-MS/MS. | Golizeh, M. and Sleno, L. 2013. J Proteomics. 82: 166-78. PMID: 23454493
- A Guide to Differential Scanning Calorimetry of Membrane and Soluble Proteins in Detergents. | Yang, Z. and Brouillette, CG. 2016. Methods Enzymol. 567: 319-58. PMID: 26794360
- Molecular dynamics study of micelles properties according to their size. | Lebecque, S., et al. 2017. J Mol Graph Model. 72: 6-15. PMID: 27992815
- Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies. | Chipot, C., et al. 2018. Chem Rev. 118: 3559-3607. PMID: 29488756
- A serine in the first transmembrane domain of the human E3 ubiquitin ligase MARCH9 is critical for down-regulation of its protein substrates. | Tan, C., et al. 2019. J Biol Chem. 294: 2470-2485. PMID: 30554144
- Implicit Micelle Model for Membrane Proteins Using Superellipsoid Approximation. | Mori, T. and Sugita, Y. 2020. J Chem Theory Comput. 16: 711-724. PMID: 31765139
- A continuous assay for O-alkylglycerol monooxygenase (E.C. 1.14.16.5). | Koetting, J., et al. 1987. Lipids. 22: 824-30. PMID: 3444373
- Hexadecylphosphocholine differs from conventional cytostatic agents. | Berger, MR., et al. 1993. J Cancer Res Clin Oncol. 119: 541-8. PMID: 8392075
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tetradecyl-phosphocholine, 250 mg | sc-205978 | 250 mg | $204.00 | |||
Tetradecyl-phosphocholine, 1 g | sc-205978A | 1 g | $408.00 |