Molecular structure of Tetracaine hydrochloride, CAS Number: 136-47-0
Tetracaine hydrochloride (CAS 136-47-0)
Alternate Names:
4-Butylaminobenzoic acid dimethylaminoethyl ester HCl
Application:
Tetracaine hydrochloride is a calcium channel protein inhibitor
CAS Number:
136-47-0
Purity:
≥99%
Molecular Weight:
300.82
Molecular Formula:
C15H24N2O2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tetracaine hydrochloride is a compound that functions as a local anesthetic by blocking the initiation and conduction of nerve impulses. It achieves this by inhibiting the influx of sodium ions through the cell membrane, which prevents the generation of action potentials. Tetracaine Hydrochloride acts by binding to specific voltage-gated sodium channels in the neuronal membrane, thereby reducing their permeability to sodium ions. Tetracaine hydrochloride interferes with the depolarization of the neuronal membrane, leading to the suppression of nerve signal transmission. This mechanism of action may be a useful for studying the role of sodium channels in neuronal signaling and for investigating the physiological processes that involve nerve impulse transmission.
Tetracaine hydrochloride (CAS 136-47-0) References
- Aerosol-OT microemulsions as transdermal carriers of tetracaine hydrochloride. | Changez, M. and Varshney, M. 2000. Drug Dev Ind Pharm. 26: 507-12. PMID: 10789062
- Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: in vivo. | Changez, M., et al. 2006. Colloids Surf B Biointerfaces. 48: 58-66. PMID: 16497490
- Non-equilibrium determination of metoclopramide and tetracaine hydrochloride by sequential injection spectrophotometry. | Fan, J., et al. 2005. Talanta. 66: 236-43. PMID: 18969987
- Determination of tetracaine hydrochloride by fluorescence quenching method with some aromatic amino acids as probes. | Gan, X., et al. 2012. J Fluoresc. 22: 129-35. PMID: 21822580
- Antibacterial effect of tetracaine hydrochloride (Pontocaine) in the aspect of exposure time--in vitro study. | Kang, SW. and Lee, JH. 1989. Korean J Ophthalmol. 3: 11-3. PMID: 2507807
- Exponential Decay Metrics of Topical Tetracaine Hydrochloride Administration Describe Corneal Anesthesia Properties Mechanistically. | Ethington, J., et al. 2017. Cornea. 36: 363-366. PMID: 28060026
- Effect of Topical 1% Tetracaine Hydrochloride on Intraocular Pressure in Ophthalmologically Normal Horses; a Pilot Study. | Faghihi, H., et al. 2020. J Equine Vet Sci. 95: 103296. PMID: 33276925
- Effect of topical 0.5% tetracaine hydrochloride on intraocular pressure in ophthalmologically normal cats. | Faghihi, H., et al. 2022. J Feline Med Surg. 24: 185-188. PMID: 33908304
- Tetracaine hydrochloride induces cell cycle arrest in melanoma by downregulating hnRNPA1. | Huang, X., et al. 2022. Toxicol Appl Pharmacol. 434: 115810. PMID: 34822839
- Mixed Micellization, Thermodynamic and Adsorption Behavior of Tetracaine Hydrochloride in the Presence of Cationic Gemini/Conventional Surfactants. | Azum, N., et al. 2022. Gels. 8: PMID: 35200509
- Rapid and sensitive simultaneous separation and electrochemical detection of tetracaine hydrochloride and oxymetazoline hydrochloride in pharmaceutical formulations via core-shell reversed-phase liquid chromatography. | Alghamdi, H., et al. 2022. J Pharm Biomed Anal. 214: 114717. PMID: 35358771
- Characterization of seven new related impurities and forced degradation products of tetracaine hydrochloride and proposal of degradation pathway by UHPLC-Q-TOF-MS. | Liu, C., et al. 2023. J Pharm Biomed Anal. 223: 115116. PMID: 36343535
- Mechanism of action of tetracaine hydrochloride against Pseudomonas aeruginosa. | Leung, YW. and Rawal, BD. 1977. J Infect Dis. 136: 679-83. PMID: 410897
Inhibitor of:
Calcium Channel Protein, Na+ CP type IV alpha, and Na+ CP type X alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tetracaine hydrochloride, 5 g | sc-251166 | 5 g | $51.00 | |||
Tetracaine hydrochloride, 25 g | sc-251166A | 25 g | $93.00 |