Date published: 2026-5-14

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Tetrabutylphosphonium hydroxide solution (CAS 14518-69-5)

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Alternate Names:
TBPH solution
CAS Number:
14518-69-5
Molecular Weight:
276.44
Molecular Formula:
C16H37OP
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetrabutylphosphonium hydroxide solution (TBPOH) is a quaternary ammonium hydroxide salt. It is a strong base, with a pKa of 12.7, and is in a variety of scientific applications. Tetrabutylphosphonium hydroxide solution serves as a catalyst in organic synthesis, an electrolyte in electrochemical reactions, and an enzyme inhibitor in biochemistry and physiology. In biochemistry, Tetrabutylphosphonium hydroxide solution may act to inhibit cytochrome P450 enzymes and proteases. Physiologically, it demonstrates both anti-inflammatory and anti-angiogenic properties, implying that it hinders new blood vessel development. Tetrabutylphosphonium hydroxide solution has a protective effect on cells, helping to prevent cell death.


Tetrabutylphosphonium hydroxide solution (CAS 14518-69-5) References

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  2. Ionic liquid versus prodrug strategy to address formulation challenges.  |  Balk, A., et al. 2015. Pharm Res. 32: 2154-67. PMID: 25534684
  3. 'Pro et contra' ionic liquid drugs - Challenges and opportunities for pharmaceutical translation.  |  Balk, A., et al. 2015. Eur J Pharm Biopharm. 94: 291-304. PMID: 26070389
  4. Electrochemical Capture and Release of Carbon Dioxide Using a Disulfide-Thiocarbonate Redox Cycle.  |  Singh, P., et al. 2017. J Am Chem Soc. 139: 1033-1036. PMID: 28052189
  5. Evaluation of several ionic liquids for in situ hydrolysis of empty fruit bunches by locally-produced cellulase.  |  Elgharbawy, AA., et al. 2016. 3 Biotech. 6: 128. PMID: 28330203
  6. Introducing the Bipolar Solvent Media Using the Aqueous Mixtures of Amino Acid Anion-Based Ionic Liquids.  |  Beniwal, V. and Kumar, A. 2017. J Phys Chem B. 121: 11367-11375. PMID: 29206038
  7. Understanding the Chemical Reactivity of Phosphonium-Based Ionic Liquids with Tellurium.  |  Zhang, T., et al. 2018. Chemistry. 24: 9325-9332. PMID: 29762892
  8. The Effect of Additives on the Viscosity and Dissolution of Cellulose in Tetrabutylphosphonium Hydroxide.  |  Nguyen, MN., et al. 2019. ChemSusChem. 12: 3458-3462. PMID: 31161712
  9. Towards the differential diagnosis of prostate cancer by the pre-treatment of human urine using ionic liquids.  |  Pereira, MM., et al. 2020. Sci Rep. 10: 14931. PMID: 32913223

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetrabutylphosphonium hydroxide solution, 100 ml

sc-251164
100 ml
$140.00