Date published: 2025-12-18

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Tetrabutylphosphonium bromide (CAS 3115-68-2)

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Alternate Names:
Tetra-N-butylphosphonium bromide
Application:
Tetrabutylphosphonium bromide is a useful synthetic reagent used in proteomics research.
CAS Number:
3115-68-2
Purity:
≥98%
Molecular Weight:
339.33
Molecular Formula:
C16H36BrP
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetrabutylphosphonium bromide is an ionic glycol ester containing a tetra-n-butyl group. When reacted with trifluoroacetic acid, it forms the water-soluble acid complex of phosphonic acid. Due to its high activity index, this molecule is more likely to react than others. Tetrabutylphosphonium bromide demonstrates biological properties, including the ability to inhibit the growth of bacteria and fungi. It serves as an ion pair reagent and an effective phase transfer catalyst.


Tetrabutylphosphonium bromide (CAS 3115-68-2) References

  1. Selective n,n-dibenzylation of primary aliphatic amines with dibenzyl carbonate in the presence of phosphonium salts.  |  Loris, A., et al. 2004. J Org Chem. 69: 3953-6. PMID: 15153031
  2. Activity of surface active substances determined from their surface excess.  |  Andersson, G., et al. 2005. Phys Chem Chem Phys. 7: 136-42. PMID: 19785182
  3. Effect of guest-host hydrogen bonding on the structures and properties of clathrate hydrates.  |  Alavi, S., et al. 2010. Chemistry. 16: 1017-25. PMID: 19946907
  4. Insights into Epoxy Network Nanostructural Heterogeneity Using AFM-IR.  |  Morsch, S., et al. 2016. ACS Appl Mater Interfaces. 8: 959-66. PMID: 26694687
  5. Chemoselective Alternating Copolymerization of Limonene Dioxide and Carbon Dioxide: A New Highly Functional Aliphatic Epoxy Polycarbonate.  |  Li, C., et al. 2016. Angew Chem Int Ed Engl. 55: 11572-6. PMID: 27529815
  6. Tetrabutylphosphonium Bromide Reduces Size and Polydispersity Index of Tat2:siRNA Nano-Complexes for Triticale RNAi.  |  Pepper, JT., et al. 2017. Front Mol Biosci. 4: 30. PMID: 28560213
  7. Preparation and Comparative Stability of a Kaolinite-Tetrabutylphosphonium Bromide Intercalation Compound for Heat and Solvent Treatments.  |  Machida, S., et al. 2019. Langmuir. 35: 13553-13561. PMID: 31538790
  8. Access to Substituted Thiophenes through Xanthate-Mediated Vinyl C(sp2)-Br Bond Cleavage and Heterocyclization of Bromoenynes.  |  Huang, G., et al. 2020. J Org Chem. 85: 13037-13049. PMID: 32909752
  9. Performance of p-Toluenesulfonic Acid-Based Deep Eutectic Solvent in Denitrogenation: Computational Screening and Experimental Validation.  |  Kamarudin, AF., et al. 2020. Molecules. 25: PMID: 33152997
  10. Vapor Pressure Assessment of Sulfolane-Based Eutectic Solvents: Experimental, PC-SAFT, and Molecular Dynamics.  |  Lima, F., et al. 2020. J Phys Chem B. 124: 10386-10397. PMID: 33167621
  11. Enzymatic Activity and Its Relationship with Organic Matter Characterization and Ecotoxicity to Aliivibrio fischeri of Soil Samples Exposed to Tetrabutylphosphonium Bromide.  |  Telesiński, A., et al. 2021. Sensors (Basel). 21: PMID: 33668135
  12. Combined Use of Ionic Liquid-Based Aqueous Biphasic Systems and Microfluidic Devices for the Detection of Prostate-Specific Antigen.  |  Flora, FC., et al. 2023. Biosensors (Basel). 13: PMID: 36979546
  13. Zinc (II) chloride-based deep eutectic solvents for application as electrolytes: Preparation and characterization  |  FSG Bagh, K Shahbaz, FS Mjalli, MA Hashim. 2015. Journal of Molecular Liquids. 204: 76-83.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetrabutylphosphonium bromide, 100 g

sc-251163
100 g
$97.00