Molecular structure of Tetrabutylammonium Fluoride, CAS Number: 429-41-4
Tetrabutylammonium Fluoride (CAS 429-41-4)
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Alternate Names:
TBAF; DM 235
Application:
Tetrabutylammonium Fluoride is a reactant used for the synthesis of multiple compounds
CAS Number:
429-41-4
Molecular Weight:
261.46
Molecular Formula:
C16H36FN
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tetrabutylammonium Fluoride (TBAF) is an organofluoride compound with a wide range of applications in organic synthesis, analytical chemistry, and biochemistry. It is a reactant used for the synthesis of multiple compounds, including polymers, conjugated dienoic acid esters, oligoribonucleotides with phosphonate-modified linkages, and triple monoamine reuptake inhibitors, among others. It is also used as a reagent for the deprotection of protected alcohols, for the synthesis of fluorinated compounds, for the analysis of biomolecules, and in the cleavage of disulfide bonds. It is a solution used in organic synthesis as a phase transfer catalyst and a source of fluoride ions. It facilitates various chemical reactions, including desilylation and nucleophilic substitution, in a tetrahydrofuran (THF) solvent system.
Tetrabutylammonium Fluoride (CAS 429-41-4) References
- Utilization of Tetrabutylammonium Triphenyldifluorosilicate as a Fluoride Source for Silicon-Carbon Bond Cleavage. | Pilcher, AS. and DeShong, P. 1996. J Org Chem. 61: 6901-6905. PMID: 11667585
- Anhydrous tetrabutylammonium fluoride. | Sun, H. and DiMagno, SG. 2005. J Am Chem Soc. 127: 2050-1. PMID: 15713075
- Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ. | Brik, A., et al. 2005. Bioorg Med Chem. 13: 4622-6. PMID: 15953729
- Tetrabutylammonium fluoride (TBAF)-catalyzed addition of substituted trialkylsilylalkynes to aldehydes, ketones, and trifluoromethyl ketones. | Chintareddy, VR., et al. 2011. J Org Chem. 76: 4482-8. PMID: 21517057
- Simple and convenient synthesis of esters from carboxylic acids and alkyl halides using tetrabutylammonium fluoride. | Matsumoto, K., et al. 2014. J Oleo Sci. 63: 539-44. PMID: 24770480
- The use of tetrabutylammonium fluoride to promote N- and O-(11) C-methylation reactions with iodo[(11) C]methane in dimethyl sulfoxide. | Kikuchi, T., et al. 2013. J Labelled Comp Radiopharm. 56: 672-8. PMID: 25196029
- Straightforward synthesis of 1,2-dicyanoalkanes from nitroalkenes and silyl cyanide mediated by tetrabutylammonium fluoride. | Kiyokawa, K., et al. 2015. Chemistry. 21: 1280-5. PMID: 25346107
- Synthesis of alkynes from vinyl triflates using tetrabutylammonium fluoride. | Okutani, M. and Mori, Y. 2015. Chem Pharm Bull (Tokyo). 63: 393-6. PMID: 25948333
- Direct Synthesis of α-Allenols from TMS-Protected Alkynes and Aldehydes Mediated by Tetrabutylammonium Fluoride. | Huang, X. and Bugarin, A. 2016. Chemistry. 22: 12696-700. PMID: 27401054
- Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF). | Balandeh, M., et al. 2017. J Electrochem Soc. 164: G99-G103. PMID: 28890550
- Characterization of Non-Derivatized Cellulose Samples by Size Exclusion Chromatography in Tetrabutylammonium Fluoride/Dimethylsulfoxide (TBAF/DMSO). | Rebière, J., et al. 2017. Molecules. 22: PMID: 29144402
- Design and Fabrication of Wettability Gradients with Tunable Profiles through Degrafting Organosilane Layers from Silica Surfaces by Tetrabutylammonium Fluoride. | Miles, J., et al. 2017. Langmuir. 33: 14556-14564. PMID: 29161508
- Enantioselective Catalytic Cyclopropanation-Rearrangement Approach to Chiral Spiroketals. | Dong, K., et al. 2021. Org Lett. 23: 3955-3959. PMID: 33955755
- CO2 conversion to formamide using a fluoride catalyst and metallic silicon as a reducing agent. | Wang, R., et al. 2022. Commun Chem. 5: 150. PMID: 36698012
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tetrabutylammonium Fluoride, 25 ml | sc-296487 | 25 ml | $26.00 | |||
Tetrabutylammonium Fluoride, 100 ml | sc-296487A | 100 ml | $58.00 |