Date published: 2026-5-9

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Tetrabutylammonium Fluoride Hydrate (CAS 22206-57-1)

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Alternate Names:
TBAF H2O
Application:
Tetrabutylammonium fluoride is a reagent used to prepare terminal olefins from primary alkyl iodides
CAS Number:
22206-57-1
Purity:
98%
Molecular Weight:
261.46 (anhydrous)
Molecular Formula:
C16H36FN•xH2O
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetrabutylammonium fluoride (TBAF) is a reagent used to prepare terminal olefins from primary alkyl iodides. Tetrabutylammonium fluoride is also used as a reactant for preparation of double clathrate hydrates at high pressures, cellulose ethers, terminal olefins via dehydrohalogenation reactions, neutral and zwitterionic 3-carboranyl thymidine analogues for boron neutron capture therapy.


Tetrabutylammonium Fluoride Hydrate (CAS 22206-57-1) References

  1. Anhydrous tetrabutylammonium fluoride.  |  Sun, H. and DiMagno, SG. 2005. J Am Chem Soc. 127: 2050-1. PMID: 15713075
  2. Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ.  |  Brik, A., et al. 2005. Bioorg Med Chem. 13: 4622-6. PMID: 15953729
  3. Tetrabutylammonium fluoride (TBAF)-catalyzed addition of substituted trialkylsilylalkynes to aldehydes, ketones, and trifluoromethyl ketones.  |  Chintareddy, VR., et al. 2011. J Org Chem. 76: 4482-8. PMID: 21517057
  4. Simple and convenient synthesis of esters from carboxylic acids and alkyl halides using tetrabutylammonium fluoride.  |  Matsumoto, K., et al. 2014. J Oleo Sci. 63: 539-44. PMID: 24770480
  5. The use of tetrabutylammonium fluoride to promote N- and O-(11) C-methylation reactions with iodo[(11) C]methane in dimethyl sulfoxide.  |  Kikuchi, T., et al. 2013. J Labelled Comp Radiopharm. 56: 672-8. PMID: 25196029
  6. Synthesis of alkynes from vinyl triflates using tetrabutylammonium fluoride.  |  Okutani, M. and Mori, Y. 2015. Chem Pharm Bull (Tokyo). 63: 393-6. PMID: 25948333
  7. Direct Synthesis of α-Allenols from TMS-Protected Alkynes and Aldehydes Mediated by Tetrabutylammonium Fluoride.  |  Huang, X. and Bugarin, A. 2016. Chemistry. 22: 12696-700. PMID: 27401054
  8. Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF).  |  Balandeh, M., et al. 2017. J Electrochem Soc. 164: G99-G103. PMID: 28890550
  9. Characterization of Non-Derivatized Cellulose Samples by Size Exclusion Chromatography in Tetrabutylammonium Fluoride/Dimethylsulfoxide (TBAF/DMSO).  |  Rebière, J., et al. 2017. Molecules. 22: PMID: 29144402
  10. Mechanochemical esterification of waste mulberry wood by wet Ball-milling with tetrabutylammonium fluoride.  |  Chen, J., et al. 2019. Bioresour Technol. 285: 121354. PMID: 31004953
  11. Dependence of deposition method on the molecular structure and stability of organosilanes revealed from degrafting by tetrabutylammonium fluoride.  |  Miles, J., et al. 2020. Phys Chem Chem Phys. 22: 658-666. PMID: 31829362
  12. Fluoride-Triggered Self-Degradation of Poly(2,4-disubstitued 4-hydroxybutyric acid) Derivatives.  |  Kan, XW., et al. 2021. Macromol Rapid Commun. 42: e2100169. PMID: 34028933
  13. CO2 conversion to formamide using a fluoride catalyst and metallic silicon as a reducing agent.  |  Wang, R., et al. 2022. Commun Chem. 5: 150. PMID: 36698012

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetrabutylammonium Fluoride Hydrate, 25 g

sc-251153
25 g
$73.00

Tetrabutylammonium Fluoride Hydrate, 500 g

sc-251153A
500 g
$243.00

Tetrabutylammonium Fluoride Hydrate, 1 kg

sc-251153B
1 kg
$486.00