Tetra-O-acetyl-a-Mannosyl-Fmoc serine (CAS 118358-80-8)

Tetra-O-acetyl-a-mannosyl-Fmoc serine, with its complex structure, serves as a specialized reagent in the field of glycochemistry and peptide synthesis. This chemical compound combines both a sugar moiety, specifically a mannose derivative, and an amino acid, serine, which is protected by the fluorenylmethyloxycarbonyl (Fmoc) group. The mannose sugar is modified by acetylation, which protects the hydroxyl groups during synthetic procedures and increases its compatibility with organic solvents. The Fmoc protection on the serine amino group allows this compound to be used effectively in solid-phase peptide synthesis, a method widely used for the assembly of peptides while protecting the amino group from unwanted reactions during the coupling of peptide chains. The presence of the mannose residue makes it particularly useful in the synthesis of glycopeptides, which are peptides that contain carbohydrate groups. These glycopeptides are crucial for studying protein-carbohydrate interactions that are central to many biological processes, including cell signaling and immune response. In research, Tetra-O-acetyl-a-mannosyl-Fmoc serine is employed to systematically study these interactions, helping scientists to understand how sugars influence peptide structure and function, and to develop molecules that can potentially mimic or disrupt these biological pathways in controlled experiments, excluding any therapeutic or pharmaceutical contexts.