tert-Butyl tetraisopropylphosphorodiamidite (CAS 137348-88-0)

Tert-Butyl tetraisopropylphosphorodiamidite (TBDTIP) is a versatile and commercially available reagent extensively employed in organic synthesis. Its applications span a wide range of scientific research, including the synthesis of peptides, oligonucleotides, proteins, carbohydrates, and other nitrogen-containing and organic compounds. Tert-Butyl tetraisopropylphosphorodiamidite serves as useful due to its high reactivity and compatibility with various reaction conditions. As a highly reactive reagent, Tert-Butyl tetraisopropylphosphorodiamidite forms a covalent bond with the nitrogen atom of the substrate, leading to a cyclization reaction and the formation of a cyclic intermediate. Subsequent rearrangement of this intermediate produces the desired product. Its efficacy, coupled with its affordability, makes Tert-Butyl tetraisopropylphosphorodiamidite an attractive choice for the synthesis of pharmaceuticals, agrochemicals, specialty chemicals, and other compounds in the field of organic chemistry.