tert-butyl 4-(chlorosulfonyl)piperazine-1-carboxylate (CAS 162046-65-3)

Tert-butyl 4-(chlorosulfonyl)piperazine-1-carboxylate, also referred to as TBCP, is an organosulfur compound widely employed in organic synthesis. With its versatility as a reagent, it finds application in various reactions, including nucleophilic substitution, Friedel-Crafts alkylation, and Michael addition. Tert-butyl 4-(chlorosulfonyl)piperazine-1-carboxylate is particularly valuable in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Its low boiling point and relative non-toxicity contribute to its suitability as a reagent for a multitude of applications. Within scientific research, Tert-butyl 4-(chlorosulfonyl)piperazine-1-carboxylate is extensively utilized. It plays a vital role in pharmaceutical and agrochemical synthesis, contributing to the production of essential compounds in these fields. Furthermore, it finds utility in the synthesis of organic compounds, peptides, proteins, and metal complexes. Its application extends to the synthesis of organic polymers and other materials, offering a versatile tool for researchers. Functioning as a nucleophilic reagent, Tert-butyl 4-(chlorosulfonyl)piperazine-1-carboxylate readily reacts with electrophiles, such as carbonyl compounds, resulting in the formation of new bonds. This reaction proceeds through a nucleophilic substitution mechanism, where the electrophile replaces the chlorine atom within the Tert-butyl 4-(chlorosulfonyl)piperazine-1-carboxylate molecule. It is important to note that this reaction is typically reversible, and the product can be isolated through distillation techniques.