Territrem B (CAS 70407-20-4)
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Territrem B, a mycotoxin exerts its action through several key molecular mechanisms. It inhibits the release of acetylcholine, a critical neurotransmitter, which disrupts synaptic transmission and affects neural communication. Territrem B further impacts neuronal activity by interfering with the function of voltage-gated sodium channels, leading to a blockade of depolarization and an impairment of neuronal signaling. The influence of Territrem B extends to the modulation of calcium channel activities, which causes a dysregulation of intracellular calcium levels, adding another layer of complexity to its neurotoxic profile. The perturbation in calcium signaling plays a significant role in numerous neuronal processes. Territrem B contributes to oxidative stress and mitochondrial dysfunction within neuronal cells, factors that exacerbate its neurotoxicity.
Territrem B (CAS 70407-20-4) References
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- Production of polyclonal antibodies against territrem B and detection of territrem B in the conidia of Aspergillus terreus 23-1 by immunoelectron microscopy. | Peng, FC., et al. 2004. J Agric Food Chem. 52: 3360-5. PMID: 15161198
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Territrem B, 500 µg | sc-203293 | 500 µg | $148.00 | |||
Territrem B, 1 mg | sc-203293A | 1 mg | $287.00 |