Territrem B CAS: 70407-20-4
MF: C29H34O9
MW: 526.6
A potent and irreversible inhibitor of acetylcholinesterase.

Territrem B (CAS 70407-20-4)

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Application: Territrem B is a potent and irreversible inhibitor of acetylcholinesterase
CAS Number: 70407-20-4
Purity: >95%
Molecular Weight: 526.6
Molecular Formula: C29H34O9
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Territrem B, a tremorgenic mycotoxin originally derived from a rice culture of Aspergillus terreus, has been reported to potently and selectively inhibit AChE (acetylcholinesterase). The irreversible inhibition of AChE by this compound is thought to be enhanced by a high concentration of NaCl and prevented by Triton (sc-29112) X-100.


References

1. Arvanov, V.L., et al. 1993. Neurosci. Lett. 152: 69-71. PMID: 8100056
2. Peng, F.C. 1995. J. Nat. Prod. 58: 857-862. PMID: 7673929
3. Chen, J.W., et al. 1999. J. Biol. Chem. 274: 34916-34923. PMID: 10574966
4. Peng, F.C., et al. 2004. J. Agric. Food Chem. 52: 3360-3365. PMID: 15161198

Physical State :
Solid
Derived From :
Aspergillus terreus.
Solubility :
Soluble in methanol, and chloroform. Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
692.99° C at 760 mmHg (Predicted)
Density :
1.36 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
acetylcholinesterase: IC50 = 8 nM
pK Values :
pKa: 12.11 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
QL6284000
PubChem CID :
114734
MDL Number :
MFCD00869655
SMILES :
C[[email protected]@]12CC[[email protected]@]3([[email protected]@]([[email protected]]1(CC4=C(O2)C=C(OC4=O)C5=CC(=C(C(=C5)OC)OC)OC)O)(C(=O)C=CC3(C)C)C)O

Download SDS (MSDS)

Certificate of Analysis

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