Date published: 2025-10-18

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Terpinolene (CAS 586-62-9)

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Alternate Names:
4-Isopropylidene-1-methylcyclohexene; p-Meth-1-en-8-yl-formate; p-Menth-1,4(8)-diene
Application:
Terpinolene is a biogenically emitted monoterpene found in nature and in large amounts in Clausena indica
CAS Number:
586-62-9
Molecular Weight:
136.23
Molecular Formula:
C10H16
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Terpinolene, a member of the terpene class of organic compounds, exhibits aromatic properties and is categorized as a monoterpene. This versatile compound is present in various essential oils like tea tree, nutmeg, and eucalyptus. Scientific research has explored its potential to inhibit the growth of specific bacteria, fungi, and viruses. While the exact mechanism remains under study, terpinolene is believed to function as an antioxidant, scavenging free radicals to safeguard cells from oxidative damage.


Terpinolene (CAS 586-62-9) References

  1. Monoterpenoid accumulation in 1,8-cineole, terpinolene and terpinen-4-ol chemotypes of Melaleuca alternifolia seedlings.  |  Russell, MF. and Southwell, IA. 2003. Phytochemistry. 62: 683-9. PMID: 12620320
  2. Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells.  |  Okumura, N., et al. 2012. Oncol Lett. 3: 321-324. PMID: 22740904
  3. The sedative effect of inhaled terpinolene in mice and its structure-activity relationships.  |  Ito, K. and Ito, M. 2013. J Nat Med. 67: 833-7. PMID: 23339024
  4. Toxic effects of terpinolene on Microcystis aeruginosa: Physiological, metabolism, gene transcription, and growth effects.  |  Zhao, P., et al. 2020. Sci Total Environ. 719: 137376. PMID: 32135322
  5. Potentiation of antifungal activity of terbinafine by dihydrojasmone and terpinolene against dermatophytes.  |  Pinto, ÂV., et al. 2021. Lett Appl Microbiol. 72: 292-298. PMID: 32790923
  6. Effect of terpinolene against the resistant Staphylococcus aureus strain, carrier of the efflux pump QacC and β-lactamase gene, and its toxicity in the Drosophila melanogaster model.  |  Scherf, JR., et al. 2020. Microb Pathog. 149: 104528. PMID: 33002597
  7. Are thymol, rosefuran, terpinolene and umbelliferone good scavengers of peroxyl radicals?  |  Boulebd, H. 2021. Phytochemistry. 184: 112670. PMID: 33524861
  8. Hormones induce the metabolic growth and cytotoxin production of Microcystis aeruginosa under terpinolene stress.  |  Anam, GB., et al. 2021. Sci Total Environ. 769: 145083. PMID: 33736237
  9. RIFM fragrance ingredient safety assessment, terpinolene, CAS Registry Number 586-62-9.  |  Api, AM., et al. 2022. Food Chem Toxicol. 167 Suppl 1: 113195. PMID: 35662620
  10. Highly selective acid-catalyzed olefin isomerization of limonene to terpinolene by kinetic suppression of overreactions in a confined space of porous metal-macrocycle frameworks.  |  He, W., et al. 2022. Chem Sci. 13: 8752-8758. PMID: 35975147
  11. Correction: Highly selective acid-catalyzed olefin isomerization of limonene to terpinolene by kinetic suppression of overreactions in a confined space of porous metal-macrocycle frameworks.  |  He, W., et al. 2022. Chem Sci. 13: 9787-9790. PMID: 36091891

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Terpinolene, 100 ml

sc-236969
100 ml
$46.00