Terpendole E (CAS 167427-23-8)
Alternate Names:
1′α-Hydroxy-paspaline; FO 2546L
Application:
Terpendole E is a ACAT and Eg5 inhibitor
CAS Number:
167427-23-8
Molecular Weight:
437.6
Molecular Formula:
C28H39NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Terpendole E is a ACAT (Acyl-CoA:cholesterol acyltransferase) and Eg5 (Mitotic Kinesin Spindle Protein) inhibitor. Also a specific inhibitor of M phase.
Terpendole E (CAS 167427-23-8) References
- A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5. | Nakazawa, J., et al. 2003. Chem Biol. 10: 131-7. PMID: 12618185
- Development and application of bioprobes for Mammalian cell cycle analyses. | Osada, H. 2003. Curr Med Chem. 10: 727-32. PMID: 12678775
- A novel approach to indoloditerpenes by Nazarov photocyclization: synthesis and biological investigations of terpendole E analogues. | Churruca, F., et al. 2010. Org Lett. 12: 2096-9. PMID: 20387880
- Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. | Oishi, S., et al. 2010. J Med Chem. 53: 5054-8. PMID: 20521839
- Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba. | Motoyama, T., et al. 2012. Chem Biol. 19: 1611-9. PMID: 23261604
- Terpendole E and its derivative inhibit STLC- and GSK-1-resistant Eg5. | Tarui, Y., et al. 2014. Chembiochem. 15: 934-8. PMID: 24648249
- Detection of oxygen addition peaks for terpendole E and related indole-diterpene alkaloids in a positive-mode ESI-MS. | Hongo, Y., et al. 2014. J Mass Spectrom. 49: 537-42. PMID: 24913406
- Synthesis of (±)-terpendole E. | Teranishi, T., et al. 2015. Biosci Biotechnol Biochem. 79: 11-5. PMID: 25184606
- Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism. | Motoyama, T. and Osada, H. 2016. Bioorg Med Chem Lett. 26: 5843-5850. PMID: 27865702
- Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data. | Sheff, JG., et al. 2017. Mol Cell Proteomics. 16: 428-437. PMID: 28062800
- Identification of Indole Diterpenes in Ipomoea asarifolia and Ipomoea muelleri, Plants Tremorgenic to Livestock. | Lee, ST., et al. 2017. J Agric Food Chem. 65: 5266-5277. PMID: 28571312
- Detection of the tremorgenic mycotoxin paxilline and its desoxy analog in ergot of rye and barley: a new class of mycotoxins added to an old problem. | Bauer, JI., et al. 2017. Anal Bioanal Chem. 409: 5101-5112. PMID: 28674820
- The Known Antimammalian and Insecticidal Alkaloids Are Not Responsible for the Antifungal Activity of Epichloë Endophytes. | Fernando, K., et al. 2021. Plants (Basel). 10: PMID: 34834850
- Identification, Characterization, and Evaluation of Nematophagous Fungal Species of Arthrobotrys and Tolypocladium for the Management of Meloidogyne incognita. | Kassam, R., et al. 2021. Front Microbiol. 12: 790223. PMID: 34956156
Inhibitor of:
ACAT, and Eg5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Terpendole E, 1 mg | sc-391039 | 1 mg | $240.00 |