Date published: 2025-12-5

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Terizidone (CAS 25683-71-0)

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Alternate Names:
4,4′-[1,4-Phenylenebis(methylidynenitrilo)]bis-3-isoxazolidinone
CAS Number:
25683-71-0
Molecular Weight:
302.29
Molecular Formula:
C14H14N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Terizidone is a cycloserine derivative utilized predominantly in microbiological research, particularly in the study of bacterial resistance mechanisms. Its core mechanism involves the inhibition of cell wall synthesis in bacteria, making it useful for probing the intricate processes that bacteria use to resist antibacterial agents. Terizidone specifically targets the alanine racemase and D-alanine:D-alanine ligase enzymes, for peptidoglycan formation, which is essential for bacterial cell wall integrity. By disrupting these enzymatic pathways, terizidone helps researchers understand how alterations in bacterial cell wall synthesis contribute to resistance. This attribute makes terizidone a critical compound in the exploration of novel antimicrobial strategies and in the broader field of bacterial pathogenesis. Its application in laboratory applications facilitates the development of more effective antibacterial agents, as well as enhanced strategies for overcoming bacterial resistance.


Terizidone (CAS 25683-71-0) References

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  8. Steady state pharmacokinetics of cycloserine in patients on terizidone for multidrug-resistant tuberculosis.  |  Court, R., et al. 2018. Int J Tuberc Lung Dis. 22: 30-33. PMID: 29297422
  9. Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug-resistant tuberculosis.  |  Mulubwa, M. and Mugabo, P. 2018. Biomed Chromatogr. 32: e4325. PMID: 29947117
  10. Steady-state population pharmacokinetics of terizidone and its metabolite cycloserine in patients with drug-resistant tuberculosis.  |  Mulubwa, M. and Mugabo, P. 2019. Br J Clin Pharmacol. 85: 1946-1956. PMID: 31046167
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Terizidone, 10 mg

sc-475059A
10 mg
$129.00

Terizidone, 25 mg

sc-475059
25 mg
$202.00

Terizidone, 100 mg

sc-475059B
100 mg
$662.00

Terizidone, 1 g

sc-475059C
1 g
$1770.00