Molecular structure of Terfenadone, CAS Number: 43076-30-8
Terfenadone (CAS 43076-30-8)
Alternate Names:
1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-butanone
Application:
Terfenadone is a compound with potential antihistamine properties in vitro, additionally inhibits CD81-receptor HCV-E2 interactions
CAS Number:
43076-30-8
Molecular Weight:
469.66
Molecular Formula:
C32H39NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Terfenadone is a compound with potential antihistamine properties in vitro. It has also been seen in vitro to inhibitor human cells from having the CD81-receptor HCV-E2 interaction. It acts similar to Benzyl Salicylate (sc-254966).
Terfenadone (CAS 43076-30-8) References
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- Structural control of cytochrome P450-catalyzed ω-hydroxylation. | Johnston, JB., et al. 2011. Arch Biochem Biophys. 507: 86-94. PMID: 20727847
- A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis. | Lombard, M., et al. 2011. Arch Biochem Biophys. 508: 54-63. PMID: 21241658
- Danazol Inhibits Cytochrome P450 2J2 Activity in a Substrate-independent Manner. | Lee, E., et al. 2015. Drug Metab Dispos. 43: 1250-3. PMID: 26048912
- Spectral and 3D model studies of the interaction of orphan human cytochrome P450 2U1 with substrates and ligands. | Dhers, L., et al. 2017. Biochim Biophys Acta Gen Subj. 1861: 3144-3153. PMID: 27456766
- Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine. | Ikemura, N., et al. 2019. Chem Biol Interact. 306: 1-9. PMID: 30965050
- Molecular determinant of substrate binding and specificity of cytochrome P450 2J2. | Xu, L. and Chen, LY. 2020. Sci Rep. 10: 22267. PMID: 33335233
- Cytochrome P450 2J2 inhibits the proliferation and angiogenesis of retinal vascular endothelial cells by regulating the Notch signaling pathway in a hypoxia-induced retinopathy model. | Zhang, J., et al. 2021. Bioengineered. 12: 10878-10890. PMID: 34666595
- Cardiomyocyte-specific CYP2J2 and its therapeutic implications. | Valencia, R., et al. 2022. Expert Opin Drug Metab Toxicol. 18: 423-439. PMID: 35997132
- Human Orphan Cytochrome P450 2U1 Catalyzes the ω-Hydroxylation of Leukotriene B4. | Nouri, K., et al. 2022. Int J Mol Sci. 23: PMID: 36498943
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Terfenadone, 100 mg | sc-475063 | 100 mg | $359.00 |