Date published: 2026-4-24

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Terephthalamide (CAS 3010-82-0)

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Alternate Names:
p-Carbamoylbenzamide
CAS Number:
3010-82-0
Purity:
≥98%
Molecular Weight:
164.16
Molecular Formula:
C8H8N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Terephthalamide (TPA), a synthetic compound, has gained significant popularity in the fields of chemistry and biochemistry due to its desirable properties. This non-toxic and biodegradable compound exists as a white, crystalline solid, displaying solubility in water and alcohols. Scientific research has extensively utilized terephthalamide, with studies focusing on enzymes, proteins, and other biomolecules benefiting from its usage. Additionally, its utility extends to the examination of the impacts of drugs and toxins on cells and tissues. Moreover, terephthalamide plays a role in the synthesis of polymer materials like polyethylene terephthalate (PET), finding wide-ranging industrial and commercial applications. While the mechanism of action of terephthalamide is not yet fully elucidated, it is believed to function as a chelating agent, effectively binding to metal ions and impeding their participation in chemical reactions. Furthermore, it is thought to interact with proteins and other biomolecules, leading to alterations in their structure and function. Continued exploration of these mechanisms holds promise for unveiling further insights into terephthalamide′s behavior and its potential applications across various domains.


Terephthalamide (CAS 3010-82-0) References

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  2. Tuning the coordination number of hydroxypyridonate-based gadolinium complexes: implications for MRI contrast agents.  |  Pierre, VC., et al. 2006. J Am Chem Soc. 128: 5344-5. PMID: 16620097
  3. Synthesis and thermodynamic evaluation of mixed hexadentate linear iron chelators containing hydroxypyridinone and terephthalamide units.  |  Abergel, RJ. and Raymond, KN. 2006. Inorg Chem. 45: 3622-31. PMID: 16634594
  4. 1,2-hydroxypyridonate/terephthalamide complexes of gadolinium(III): synthesis, stability, relaxivity, and water exchange properties.  |  Werner, EJ., et al. 2009. Inorg Chem. 48: 277-86. PMID: 19032045
  5. Non-peptidic α-helical mimetics as protein-protein interaction inhibitors.  |  Dewal, MB. and Firestine, SM. 2011. Curr Med Chem. 18: 2420-8. PMID: 21568916
  6. Improving T₁ and T₂ magnetic resonance imaging contrast agents through the conjugation of an esteramide dendrimer to high-water-coordination Gd(III) hydroxypyridinone complexes.  |  Klemm, PJ., et al. 2012. Contrast Media Mol Imaging. 7: 95-9. PMID: 22344885
  7. Superelastic organic crystals.  |  Takamizawa, S. and Miyamoto, Y. 2014. Angew Chem Int Ed Engl. 53: 6970-3. PMID: 24800764
  8. A macrocyclic chelator with unprecedented Th⁴⁺ affinity.  |  Pham, TA., et al. 2014. J Am Chem Soc. 136: 9106-15. PMID: 24870296
  9. Direct Synthesis of a Covalent Triazine-Based Framework from Aromatic Amides.  |  Yu, SY., et al. 2018. Angew Chem Int Ed Engl. 57: 8438-8442. PMID: 29624829
  10. A new twofold interpenetrated two-dimensional cadmium(II) coordination polymer constructed from 2,2'-(benzene-1,4-dicarboxamido)dipropionate.  |  Zhang, HT. and Wang, XL. 2018. Acta Crystallogr C Struct Chem. 74: 1434-1439. PMID: 30398199
  11. Synthesis and Performance of Aromatic Polyamide Ionenes as Gas Separation Membranes.  |  O'Harra, KE., et al. 2020. Membranes (Basel). 10: PMID: 32235739
  12. Metal-templated synthesis of rigid and conformationally restricted cyclic bisporphyrins: specific retention times on a cyanopropyl-modified silica gel column.  |  Hashimoto, M., et al. 2021. Org Biomol Chem. 19: 3159-3172. PMID: 33885570
  13. A new three-dimensional twofold interpenetrated cadmium(II) metal-organic framework: synthesis, structure and photoluminescence properties.  |  Zhang, HT. and Wang, XL. 2021. Acta Crystallogr C Struct Chem. 77: 691-697. PMID: 34738539
  14. Versatile Chemical Recycling Strategies: Value-Added Chemicals from Polyester and Polycarbonate Waste.  |  Payne, JM., et al. 2022. ChemSusChem. 15: e202200255. PMID: 35114081
  15. Octadentate catecholamide ligands for Pu(IV) based on linear or preorganized molecular backbones.  |  Durbin, PW., et al. 1996. Hum Exp Toxicol. 15: 352-60. PMID: 8845226

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Terephthalamide, 25 g

sc-476100
25 g
$157.00