Molecular structure of Terbinafine hydrochloride, CAS Number: 78628-80-5
Terbinafine hydrochloride (CAS 78628-80-5)
Alternate Names:
trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride
Application:
Terbinafine hydrochloride is a squalene monooxygenase inhibitor
CAS Number:
78628-80-5
Purity:
≥99%
Molecular Weight:
327.9
Molecular Formula:
C21H25N•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Terbinafine hydrochloride is primarily used in research to explore its mechanism of action against fungal pathogens. In the laboratory, it serves as a key agent for studying the biosynthesis of ergosterol, an essential component of fungal cell membranes. By inhibiting the enzyme squalene epoxidase, terbinafine hydrochloride disrupts the ergosterol synthesis pathway, which provides insights into fungal growth and viability. Research utilizing this compound also delves into the adaptation and resistance mechanisms of fungi, as understanding the molecular basis of resistance can inform the development of new antifungal strategies. Moreover, terbinafine hydrochloride is used in the study of dermatophytes and other skin-affecting fungi, contributing to the broader field of dermatological research.
Terbinafine hydrochloride (CAS 78628-80-5) References
- Simultaneous determination of terbinafine HCL and triamcinolone acetonide by UV derivative spectrophotometry and spectrodensitometry. | El-Saharty, YS., et al. 2002. J Pharm Biomed Anal. 28: 569-80. PMID: 12008136
- Inhibitory effect of terbinafine on reactive oxygen species (ROS) generation by Candida albicans. | Sander, CS., et al. 2002. Mycoses. 45: 152-5. PMID: 12100530
- Inhibition of human vascular endothelial cells proliferation by terbinafine. | Ho, PY., et al. 2004. Int J Cancer. 111: 51-9. PMID: 15185342
- Terbinafine: mode of action and properties of the squalene epoxidase inhibition. | Ryder, NS. 1992. Br J Dermatol. 126 Suppl 39: 2-7. PMID: 1543672
- Molecular characterization of a Squalene epoxidase gene in dermatophyte pathogen Trichophyton tonsurans. | Motavaze, K., et al. 2008. Iran Biomed J. 12: 55-8. PMID: 18392096
- Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model. | Ghannoum, MA., et al. 2009. Mycoses. 52: 35-43. PMID: 18498299
- Novel topical formulations of Terbinafine-HCl for treatment of onychomycosis. | Tanrıverdi, ST. and Özer, Ö. 2013. Eur J Pharm Sci. 48: 628-36. PMID: 23295582
- Development of solid lipid nanoparticles based controlled release system for topical delivery of terbinafine hydrochloride. | Vaghasiya, H., et al. 2013. Eur J Pharm Sci. 49: 311-22. PMID: 23557842
- Formulation, characterization and ex vivo studies of terbinafine HCl liposomes for cutaneous delivery. | Sudhakar, B., et al. 2014. Curr Drug Deliv. 11: 521-30. PMID: 24410098
- In vitro assessment of pharmaceutical potential of ethosomes entrapped with terbinafine hydrochloride. | Iizhar, SA., et al. 2016. J Adv Res. 7: 453-61. PMID: 27222750
- Enhanced Ungual Permeation of Terbinafine HCl Delivered Through Liposome-Loaded Nail Lacquer Formulation Optimized by QbD Approach. | Shah, VH. and Jobanputra, A. 2018. AAPS PharmSciTech. 19: 213-224. PMID: 28681334
- Analytical methods for determination of terbinafine hydrochloride in pharmaceuticals and biological materials. | Kanakapura, B. and Penmatsa, VK. 2016. J Pharm Anal. 6: 137-149. PMID: 29403974
- Differential inhibition of fungal amd mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine. | Favre, B. and Ryder, NS. 1997. Arch Biochem Biophys. 340: 265-9. PMID: 9143330
Inhibitor of:
Angiogenesis, Lipid Biosynthesis, and Squalene epoxidase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Terbinafine hydrochloride, 100 mg | sc-200751 | 100 mg | $76.00 | |||
Terbinafine hydrochloride, 1 g | sc-200751A | 1 g | $143.00 |