Molecular structure of Tenuazonic acid, CAS Number: 610-88-8
Tenuazonic acid (CAS 610-88-8)
See product citations (2)
Application:
Tenuazonic acid is a mycotoxin natural product with antibacterial and antineoplastic effects
CAS Number:
610-88-8
Molecular Weight:
197.30
Molecular Formula:
C10H15NO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Tenuazonic acid is a mycotoxic compound exhibiting antiviral, antibacterial and antitumor activity. Tenuazonic acid inhibits protein synthesis by suppression at the ribosome. It interferes with the elongation factor 1-alpha, a key component in the translation process of protein synthesis. This action can affect cellular functions and viability. Its mode of action on protein synthesis makes it a useful tool for studying cellular processes related to protein production and regulation. Tenuazonic acid was shown to inhibit TPA induced ornithine decarboxylase (ODC) activity, and in turn suppressed mouse skin tumor promotion. It is a phytotoxic agent that may act to be a Photosystem II inhibitor.
Tenuazonic acid (CAS 610-88-8) References
- Protective effect of tenuazonic acid against dimethyl benz(a)antracene-induced skin carcinogenesis in mice. | Antony, M., et al. 2002. Teratog Carcinog Mutagen. 22: 309-14. PMID: 12111715
- Identification of tenuazonic acid as a novel type of natural photosystem II inhibitor binding in Q(B)-site of Chlamydomonas reinhardtii. | Chen, S., et al. 2007. Biochim Biophys Acta. 1767: 306-18. PMID: 17379181
- Inhibition of mouse skin tumor promotion by tenuazonic acid. | Antony, M., et al. 1991. Cancer Lett. 61: 21-5. PMID: 1764695
- Deacetyl tenuazonic acid p-toluene-sulfonyl-hydrazone. | Siegel, D., et al. 2009. Acta Crystallogr Sect E Struct Rep Online. 65: o3136. PMID: 21578857
- Deacetyl- tenuazonic acid. | Siegel, D., et al. 2009. Acta Crystallogr Sect E Struct Rep Online. 65: o1201. PMID: 21583071
- Enzyme immunoassay for tenuazonic acid in apple and tomato products. | Gross, M., et al. 2011. J Agric Food Chem. 59: 12317-22. PMID: 22054343
- Determination of Exposure to the Alternaria Mycotoxin Tenuazonic Acid and Its Isomer allo-Tenuazonic Acid in a German Population by Stable Isotope Dilution HPLC-MS(3). | Hövelmann, Y., et al. 2016. J Agric Food Chem. 64: 6641-7. PMID: 27452834
- Recent advances in tenuazonic acid as a potential herbicide. | Chen, S. and Qiang, S. 2017. Pestic Biochem Physiol. 143: 252-257. PMID: 29183600
- Mycovirus-Induced Tenuazonic Acid Production in a Rice Blast Fungus Magnaporthe oryzae. | Ninomiya, A., et al. 2020. Front Microbiol. 11: 1641. PMID: 32765467
- Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer's Disease Agents. | Poliseno, V., et al. 2021. Biomolecules. 11: PMID: 33467709
- Tenuazonic Acid-Triggered Cell Death Is the Essential Prerequisite for Alternaria alternata (Fr.) Keissler to Infect Successfully Host Ageratina adenophora. | Shi, J., et al. 2021. Cells. 10: PMID: 33922952
- Screening of tenuazonic acid production-inducing compounds and identification of NPD938 as a regulator of fungal secondary metabolism. | Motoyama, T., et al. 2021. Biosci Biotechnol Biochem. 85: 2200-2208. PMID: 34379730
- Tenuazonic acid production is dispensable for virulence, but its biosynthetic gene expression pattern is associated with the infection of Pyricularia oryzae. | Kashiwa, T., et al. 2021. Biosci Biotechnol Biochem. 86: 135-139. PMID: 34755835
- Microbial metabolites with insecticidal properties. | Cole, M. and Rolinson, GN. 1972. Appl Microbiol. 24: 660-2. PMID: 4628800
- Microbial production of tenuazonic acid analogues. | Gatenbeck, S. and Sierankiewicz, J. 1973. Antimicrob Agents Chemother. 3: 308-9. PMID: 4790594
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tenuazonic acid, 1 mg | sc-202357 | 1 mg | $127.00 | |||
Tenuazonic acid, 5 mg | sc-202357A | 5 mg | $359.00 |