Tenellin (CAS 53823-15-7)
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Tenellin is produced by species of the genus Beauveria. Structure elucidation in 1977 showed that tenellin belongs to the rare 4-hydroxypyridone class containing a dienone side chain. Little has been published on the biological activity of tenellin despite the extensive use of Beauveria species, capable of producing tenellin, as biocontrol agents for agrochemical pests. Tenellin, a fungal metabolite present in Beauveria, effectively inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes, showing inhibitions of 51%, 57%, and 74%, respectively, at a concentration of 200 μg/ml. Additionally, it exhibits cytotoxic effects on Sf9 and Sf21 insect cells, with 50% cytotoxic concentration (CC50) values of 4.84 μM and 11.95 μM, respectively.
Tenellin (CAS 53823-15-7) References
- Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires coexpression with an enoyl reductase. | Halo, LM., et al. 2008. Chembiochem. 9: 585-94. PMID: 18266306
- Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana. | Halo, LM., et al. 2008. J Am Chem Soc. 130: 17988-96. PMID: 19067514
- Nongenetic reprogramming of a fungal highly reducing polyketide synthase. | Yakasai, AA., et al. 2011. J Am Chem Soc. 133: 10990-8. PMID: 21675761
- Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite. | Fisch, KM., et al. 2011. J Am Chem Soc. 133: 16635-41. PMID: 21899331
- Structure and biosynthesis of fumosorinone, a new protein tyrosine phosphatase 1B inhibitor firstly isolated from the entomogenous fungus Isaria fumosorosea. | Liu, L., et al. 2015. Fungal Genet Biol. 81: 191-200. PMID: 25857260
- Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase. | Yang, XL., et al. 2019. Chem Sci. 10: 8478-8489. PMID: 31803427
- The Toxins of Beauveria bassiana and the Strategies to Improve Their Virulence to Insects. | Wang, H., et al. 2021. Front Microbiol. 12: 705343. PMID: 34512581
- Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches. | Chen, B., et al. 2021. mBio. 12: e0327921. PMID: 34903054
- Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining. | Chiang, CY., et al. 2023. Nat Prod Rep. 40: 89-127. PMID: 36125308
- Toxic properties of Beauveria pigments on erythrocyte membranes. | Jeffs, LB. and Khachatourians, GG. 1997. Toxicon. 35: 1351-6. PMID: 9278984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tenellin, 1 mg | sc-397298 | 1 mg | $341.00 |