Molecular structure of TEMPONE, CAS Number: 2896-70-0
TEMPONE (CAS 2896-70-0)
Alternate Names:
4-Oxo-TEMPO
Application:
TEMPONE is a useful spin trap for in vitro experiments
CAS Number:
2896-70-0
Purity:
≥98%
Molecular Weight:
170.23
Molecular Formula:
C9H16NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TEMPONE is extensively utilized in the field of chemical research, particularly in studies involving radical chemistry. This stable nitroxide radical is used as a spin label in electron paramagnetic resonance (EPR) spectroscopy. TEMPONE′s ability to detect changes in viscosity and polarity may be useful for the study of cellular membranes and protein interactions. TEMPONE is employed in polymer chemistry to study the kinetics of polymerization reactions, where its radical nature helps in tracking the radical-mediated processes.
TEMPONE (CAS 2896-70-0) References
- Metabolism of the stable nitroxyl radical 4-oxo-2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPONE). | Kroll, C. and Borchert, HH. 1999. Eur J Pharm Sci. 8: 5-9. PMID: 10072473
- TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney. | Patel, NS., et al. 2002. Free Radic Biol Med. 33: 1575-89. PMID: 12446215
- Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol. | Mitchell, JB., et al. 1991. Arch Biochem Biophys. 289: 62-70. PMID: 1654848
- Spin-label oximetry at Q- and W-band. | Subczynski, WK., et al. 2011. J Magn Reson. 209: 142-8. PMID: 21277814
- Biologically active metal-independent superoxide dismutase mimics. | Mitchell, JB., et al. 1990. Biochemistry. 29: 2802-7. PMID: 2161256
- Superoxide reaction with nitroxides. | Samuni, A., et al. 1990. Free Radic Res Commun. 9: 241-9. PMID: 2167262
- Sonochemical degradation of cyclic nitroxides in aqueous solution. | Kirschenbaum, LJ. and Riesz, P. 2012. Ultrason Sonochem. 19: 1114-9. PMID: 22361491
- High DNP efficiency of TEMPONE radicals in liquid toluene at low concentrations. | Enkin, N., et al. 2014. Phys Chem Chem Phys. 16: 8795-800. PMID: 24695794
- Cytotoxicity of commonly used nitroxide radical spin probes. | Ankel, EG., et al. 1987. Life Sci. 40: 495-8. PMID: 3027487
- Characterization of Aqueous Lower-Polarity Solvation Shells Around Amphiphilic 2,2,6,6-Tetramethylpiperidine-1-oxyl Radicals in Water. | Hunold, J., et al. 2020. J Phys Chem B. 124: 8601-8609. PMID: 32872777
- Detection of singlet oxygen by EPR: The instability of the nitroxyl radicals. | Victória, HFV., et al. 2022. Free Radic Biol Med. 180: 143-152. PMID: 34979255
- Kinetics of taurine biosynthesis metabolites with reactive oxygen species: Implications for antioxidant-based production of taurine. | Karpowicz, SJ. 2022. Biochim Biophys Acta Gen Subj. 1866: 130131. PMID: 35318954
- Rotational diffusion of TEMPONE in the cytoplasm of Chinese hamster lung cells. | Lepock, JR., et al. 1983. Biophys J. 44: 405-12. PMID: 6318842
- Photooxidation of 3,4-dihydroxyphenylalanine by hematoporphyrin in aqueous solutions: an electron spin resonance study using 2,2,6,6-tetramethyl-4-piperidone-1-oxyl (TEMPONE). | Reszka, K. and Sealy, RC. 1984. Photochem Photobiol. 39: 293-9. PMID: 6326168
- Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. | Slater, AF., et al. 1995. Biochem J. 306 (Pt 3): 771-8. PMID: 7702573
- Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine. | Dikalov, S., et al. 1997. Biochem Biophys Res Commun. 230: 54-7. PMID: 9020059
- Cytotoxicity of spin trapping compounds. | Haseloff, RF., et al. 1997. FEBS Lett. 418: 73-5. PMID: 9414098
- Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonance. | Dikalov, S., et al. 1997. Nitric Oxide. 1: 423-31. PMID: 9441913
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TEMPONE, 250 mg | sc-202832 | 250 mg | $20.00 | |||
TEMPONE, 1 g | sc-202832A | 1 g | $32.00 |