TEMPONE CAS: 2896-70-0
MF: C9H16NO2
MW: 170.23
A useful spin trap for in vitro experiments.

TEMPONE (CAS 2896-70-0)

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Alternate Names: 4-Oxo-TEMPO
Application: TEMPONE is a useful spin trap for in vitro experiments
CAS Number: 2896-70-0
Purity: ≥98%
Molecular Weight: 170.23
Molecular Formula: C9H16NO2
Supplemental Information: This product is subject to an additional Dangerous Goods shipping charge.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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TEMPONE, or 4-oxo-2,2,6,6-tetramethylpiperidine-N-oxyl, is a stable nitroxyl radical compound and a derivative of TEMPO (sc-255630) used as a spin trap agent for in vitro experiments. Reaction between TEMPONE and biologically significant reactive oxygen species can be monitored by ESR spectroscopy.


References

1. Ankel, E.G., et al. 1987. Life Sci. 40: 495-498. PMID: 3027487
2. Mitchell, J.B., et al. 1990. Biochemistry. 29: 2802-2807. PMID: 2161256
3. Samuni, A., et al. 1990. Free Radic. Res. Commun. 9: 241-249. PMID: 2167262
4. Mitchell, J.B., et al. 1991. Arch. Biochem. Biophys. 289: 62-70. PMID: 1654848
5. Slater, A.F., et al. 1995. Biochem. J. 306: 771-778. PMID: 7702573
6. Haseloff, R.F., et al. 1997. FEBS Lett. 418: 73-75. PMID: 9414098

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (partly), acetone, DMSO, 100% ethanol, and diethylether.
Storage :
Store at -20° C
Melting Point :
36-40° C
Boiling Point :
257.48° C at 760 mmHg (Predicted)
IC50 :
Plasmodium falciparum (isolate K1 / Thailand): IC50 = 12.92 µM (Plasmodium falciparum K1)
pK Values :
pKa: 12.85 (Predicted), pKb: 3.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TN9200000
PubChem CID :
520789
MDL Number :
MFCD00006187
EC Number :
220-778-7
Beilstein Registry :
1818579
SMILES :
CC1(CC(=O)CC(N1[O])(C)C)C

Download SDS (MSDS)

Certificate of Analysis

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