Telmisartan-d3 (CAS 1189889-44-8)
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Telmisartan-d3 is a deuterated version of telmisartan, where three hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. This subtle modification is used in research to study the mechanisms and metabolic fate of telmisartan without altering its chemical profile. The presence of deuterium atoms makes it possible to trace the compound using mass spectrometry or NMR spectroscopy, allowing for a detailed analysis of how the chemical is absorbed, distributed, metabolized, and excreted in biological systems. Researchers utilize Telmisartan-d3 in metabolism studies to identify potential metabolites and to understand the enzyme systems involved in the biotransformation of the parent compound. Additionally, this labeled compound is essential in the development of analytical methods where it acts as an internal standard, ensuring accuracy and precision in quantitative analyses.
Telmisartan-d3 (CAS 1189889-44-8) References
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- Bio-generation of stable isotope-labeled internal standards for absolute and relative quantitation of phase II drug metabolites in plasma samples using LC-MS/MS. | Li, P., et al. 2015. Anal Bioanal Chem. 407: 4053-63. PMID: 25804729
- Pharmacokinetics of a telmisartan/rosuvastatin fixed-dose combination: a single-dose, randomized, open-label, 2-period crossover study in healthy Korean subjects. | Chae, DW., et al. 2015. Int J Clin Pharmacol Ther. 53: 883-9. PMID: 26329347
- Analysis of the Complicated Nonlinear Pharmacokinetics of Orally Administered Telmisartan in Rats Using a Stable Isotope-IV Method. | Minami, K., et al. 2019. J Pharm Sci. 108: 2774-2780. PMID: 30922857
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Telmisartan-d3, 1 mg | sc-220197 | 1 mg | $377.00 |