Molecular structure of Telmisartan Acyl-β-D-glucuronide, CAS Number: 250780-40-6
Telmisartan Acyl-β-D-glucuronide (CAS 250780-40-6)
See product citations (2)
Alternate Names:
1-O-({4′-[(1,7′-Dimethyl-2′-propyl-1H,3′H-2,5′-bibenzimidazol-3′-yl)methyl]-2-biphenylyl}carbonyl)-β-D-glucopyranuronic acid
Application:
Telmisartan Acyl-β-D-glucuronide is a metabolite of Telmisartan
CAS Number:
250780-40-6
Purity:
≥95%
Molecular Weight:
690.74
Molecular Formula:
C39H38N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Telmisartan Acyl-β-D-glucuronide finds extensive application in diverse scientific research endeavors. Its utilization encompasses the examination of angiotensin II receptor blocking agents and the exploration of telmisartan′s impact on angiotensin II-induced hypertension. Telmisartan Acyl-β-D-glucuronide functions by obstructing the angiotensin II receptor, thereby impeding the binding of angiotensin II to the receptor. Consequently, the activation of the renin-angiotensin system is effectively prevented.
Telmisartan Acyl-β-D-glucuronide (CAS 250780-40-6) References
- Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model. | Ménochet, K., et al. 2012. J Pharmacol Exp Ther. 341: 2-15. PMID: 22190645
- Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes. | Ménochet, K., et al. 2012. Drug Metab Dispos. 40: 1744-56. PMID: 22665271
- Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys. | Furukawa, T., et al. 2014. Xenobiotica. 44: 205-16. PMID: 23962030
- Physiologically based pharmacokinetic prediction of telmisartan in human. | Li, R., et al. 2014. Drug Metab Dispos. 42: 1646-55. PMID: 25092714
- Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high resolution/high accuracy mass spectrometry. | Görgens, C., et al. 2016. J Pharm Biomed Anal. 131: 482-496. PMID: 27693991
- Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations. | Cantrill, C. and Houston, JB. 2017. J Pharm Sci. 106: 2815-2825. PMID: 28478131
- Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance. | Matsunaga, N., et al. 2019. Drug Metab Dispos. 47: 215-226. PMID: 30593544
- Densitometry and indirect normal-phase HPTLC-ESI-MS for separation and quantitation of drugs and their glucuronide metabolites from plasma. | Bhatt, NM., et al. 2019. Biomed Chromatogr. 33: e4602. PMID: 31116448
- Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated Dissociation. | Niyonsaba, E., et al. 2019. Anal Chem. 91: 11388-11396. PMID: 31381321
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Telmisartan Acyl-β-D-glucuronide, 2.5 mg | sc-222341 | 2.5 mg | $445.00 |