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Teicoplanin Complex (CAS 61036-62-2)

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Application:
Teicoplanin Complex is a complex of broad-spectrum antibiotics
CAS Number:
61036-62-2
Purity:
≥99%
Molecular Weight:
1879.64
Molecular Formula:
C88H97Cl2N9O33
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Teicoplanin complex is a glycopeptide antibiotic that functions by inhibiting bacterial cell wall synthesis. It achieves this by binding to the D-alanyl-D-alanine terminus of cell wall precursors, preventing their incorporation into the peptidoglycan matrix. This interference disrupts the integrity of the bacterial cell wall, leading to cell lysis and ultimately bacterial death. Teicoplanin Complex′s mechanism of action involves interfering with the transglycosylation and transpeptidation reactions that are necessary for the formation of the bacterial cell wall. By targeting these specific processes, Teicoplanin Complex effectively disrupts the structural integrity of the bacterial cell wall, rendering the bacteria vulnerable to osmotic lysis. This mechanism of action makes teicoplanin complex useful in studying bacterial cell wall synthesis and exploring potential strategies for combating antibiotic resistance.


Teicoplanin Complex (CAS 61036-62-2) References

  1. Statistical analysis of the adverse effects of glycopeptide antibiotics, based on pharmacokinetics and toxicokinetics (PK/TK).  |  Yoshida, M., et al. 2006. J Infect Chemother. 12: 114-8. PMID: 16826342
  2. Factors affecting the normal and branched-chain acyl moieties of teicoplanin components produced by Actinoplanes teichomyceticus.  |  Borghi, A., et al. 1991. J Gen Microbiol. 137: 587-92. PMID: 1827835
  3. Activities of two new teicoplanin amide derivatives (MDL 62211 and MDL 62873) compared with activities of teicoplanin and vancomycin against 800 recent staphylococcal isolates from France and the United States.  |  Jones, RN., et al. 1991. Antimicrob Agents Chemother. 35: 584-6. PMID: 1828137
  4. Teicoplanin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential.  |  Campoli-Richards, DM., et al. 1990. Drugs. 40: 449-86. PMID: 2146108
  5. Isolation and structure determination of two new analogs of teicoplanin, a glycopeptide antibiotic.  |  Borghi, A., et al. 1989. J Antibiot (Tokyo). 42: 361-6. PMID: 2523370
  6. Determination of teicoplanin concentrations in serum by high-pressure liquid chromatography.  |  Joos, B. and Lüthy, R. 1987. Antimicrob Agents Chemother. 31: 1222-4. PMID: 2957953
  7. Binding of teicoplanin to human serum albumin.  |  Assandri, A. and Bernareggi, A. 1987. Eur J Clin Pharmacol. 33: 191-5. PMID: 2961570
  8. Teicoplanin: a new glycopeptide antibiotic complex.  |  Babul, N. and Pasko, M. 1988. Drug Intell Clin Pharm. 22: 218-26. PMID: 2966729
  9. Application of an HPLC-MS/MS method for Teicoplanin drug substance and related impurities, part 2: Identity assignment of related impurities.  |  Tengattini, S., et al. 2019. J Pharm Biomed Anal. 168: 38-43. PMID: 30784888
  10. Comparative in vitro activities of teichomycin and other antibiotics against JK diphtheroids.  |  Jadeja, L., et al. 1983. Antimicrob Agents Chemother. 24: 145-6. PMID: 6227280
  11. Comparative in vitro activities of teichomycin and vancomycin alone and in combination with rifampin and aminoglycosides against staphylococci and enterococci.  |  Tuazon, CU. and Miller, H. 1984. Antimicrob Agents Chemother. 25: 411-2. PMID: 6233934
  12. Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. VI. Chemical degradation: physico-chemical and biological properties of acid hydrolysis products.  |  Malabarba, A., et al. 1984. J Antibiot (Tokyo). 37: 988-99. PMID: 6238927
  13. In vitro activity and human pharmacokinetics of teicoplanin.  |  Verbist, L., et al. 1984. Antimicrob Agents Chemother. 26: 881-6. PMID: 6240962
  14. Isolation and structure determination of a novel complex of the teicoplanin family.  |  Quarta, C., et al. 1996. J Antibiot (Tokyo). 49: 644-50. PMID: 8784424

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Teicoplanin Complex, 25 mg

sc-202355
25 mg
$111.00

Teicoplanin Complex, 50 mg

sc-202355A
50 mg
$141.00