Teicoplanin A3-1 (CAS 93616-27-4)

Teicoplanin A3-1, bearing the CAS number 93616-27-4, is a glycopeptide compound and a component of the broader teicoplanin complex, which is derived from the Actinoplanes teichomyceticus bacterium. This compound, like other members of the glycopeptide class, acts by binding to the D-alanyl-D-alanine termini of cell wall precursors, which prevents the transpeptidation and transglycosylation reactions necessary for bacterial cell wall synthesis. The mechanism of action of Teicoplanin A3-1 involves inhibition of the late stages of peptidoglycan synthesis, leading to cellular lysis and the eventual death of susceptible bacteria. In research settings, Teicoplanin A3-1 is utilized as a tool for studying bacterial cell wall biosynthesis and examining the efficacy of cell wall inhibitors. Its specific interaction with bacterial enzymes and precursors allows researchers to dissect the pathways involved in bacterial cell wall formation and identify potential targets for new antibacterial agents. Additionally, studies involving Teicoplanin A3-1 contribute to our understanding of resistance mechanisms, particularly how changes in the target site can reduce the efficacy of glycopeptide antibiotics. This research is crucial for developing strategies to combat resistant bacterial strains and for designing novel compounds that can bypass resistance mechanisms.