Teicoplanin A2 (Mixture of 2-1, 2-2, 2-3, 2-4 and 2-5) (CAS 91032-26-7)

Teicoplanin A2, a complex glycopeptide compound, is distinguished by its unique structural configuration, which includes a mixture of closely related components such as 2-1, 2-2, 2-3, 2-4, and 2-5. With the CAS number 91032-26-7, this chemical has garnered significant attention within the realm of microbiological research, especially in the study of Gram-positive bacterial cell wall synthesis. The mechanism of action of Teicoplanin A2 revolves around its high affinity for the D-alanyl-D-alanine terminus of cell wall precursors, which is a critical site in bacterial cell wall synthesis. By binding to this terminus, Teicoplanin A2 effectively inhibits the transglycosylation and transpeptidation steps necessary for the formation of peptidoglycan, which is essential for bacterial cell wall integrity and function. This disruption leads to the inability of bacteria to properly construct their cell wall, culminating in bacterial lysis and the inhibition of bacterial growth. This specific interaction has made Teicoplanin A2 an invaluable tool in research settings, particularly in studies focused on understanding bacterial resistance mechanisms and the development of novel antibacterial strategies. Researchers also utilize this compound to explore the dynamics of bacterial growth and the genetic basis of resistance development, providing insights that contribute to the broader scientific understanding of bacterial pathogenesis and its control.