Teicoplanin A2-3 (CAS 91032-36-9)

Teicoplanin A2-3, with the CAS number 91032-36-9, is a variant within the teicoplanin complex, a suite of glycopeptide antibiotics produced from the bacterium Actinoplanes teichomyceticus. This compound is essential for research on bacterial cell wall biosynthesis inhibition. Teicoplanin A2-3 specifically targets the D-alanyl-D-alanine moiety of peptidoglycan precursors in the cell wall, a critical interaction that inhibits the transpeptidation and transglycosylation reactions necessary for cell wall construction in gram-positive bacteria. By preventing the cross-linking of peptidoglycan chains, Teicoplanin A2-3 disrupts the structural integrity of the bacterial cell wall, leading to osmotic instability and cell rupture under normal growth conditions. In scientific studies, this compound is used to investigate the detailed mechanisms of bacterial resistance to glycopeptide antibiotics, particularly through alterations in the target site. Research with Teicoplanin A2-3 aids in understanding how bacterial pathogens evade the action of cell wall synthesis inhibitors and develop resistance, providing insights that are crucial for the development of new antibacterial strategies. Furthermore, it serves as a model to study the efficacy and binding kinetics of glycopeptides, enhancing our knowledge of their mode of action at a molecular level.