Date published: 2026-1-8

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Tegaserod Maleate (CAS 189188-57-6)

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Alternate Names:
2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide maleate
Application:
Tegaserod Maleate is a SR-4 partial agonist
CAS Number:
189188-57-6
Purity:
≥97%
Molecular Weight:
417.46
Molecular Formula:
C20H27N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tegaserod Maleate is a compound utilized in research that focuses on the study of biological receptors and signal transduction pathways. Specifically, it is of interest in the investigation of serotonin receptor function and its role in the regulation of gastrointestinal motility. In the realm of biochemistry, Tegaserod Maleate is used to understand the interaction between ligands and their receptors, and how this interaction affects downstream signaling events. Researchers also use this compound to explore the molecular mechanisms underlying the movement of substances through the intestines. Additionally, Tegaserod Maleate is involved in studies related to the nervous system′s influence on the gastrointestinal tract, providing insights into the complex interplay between neurotransmitters and their physiological effects.


Tegaserod Maleate (CAS 189188-57-6) References

  1. Mosapride citrate improves postoperative ileus of patients with colectomy.  |  Toyomasu, Y., et al. 2011. J Gastrointest Surg. 15: 1361-7. PMID: 21607794
  2. Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling.  |  Zhang, L., et al. 2020. Invest New Drugs. 38: 311-320. PMID: 31087223
  3. A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle.  |  Chen, X., et al. 2020. Blood. 136: 898-908. PMID: 32374827
  4. Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway.  |  Wu, X., et al. 2021. Front Oncol. 11: 683241. PMID: 34422635
  5. A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae.  |  Sun, L., et al. 2021. Front Cell Infect Microbiol. 11: 809542. PMID: 35071055
  6. Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy.  |  Li, X., et al. 2022. J Oncol. 2022: 5320421. PMID: 35154317
  7. Combining CRISPRi and metabolomics for functional annotation of compound libraries.  |  Anglada-Girotto, M., et al. 2022. Nat Chem Biol. 18: 482-491. PMID: 35194207
  8. Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A.  |  Bao, Z., et al. 2022. Cell Death Dis. 13: 189. PMID: 35217647
  9. The DevTox Germ Layer Reporter Platform: An Assay Adaptation of the Human Pluripotent Stem Cell Test.  |  Gamble, JT., et al. 2022. Toxics. 10: PMID: 35878297
  10. Tegaserod Maleate Suppresses the Growth of Gastric Cancer In Vivo and In Vitro by Targeting MEK1/2.  |  Wang, Z., et al. 2022. Cancers (Basel). 14: PMID: 35892850
  11. Tegaserod maleate exhibits antileukemic activity by targeting TRPM8.  |  Xie, X., et al. 2022. Biomed Pharmacother. 154: 113566. PMID: 35994820
  12. Lactobacillus rhamnosus GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota.  |  Gu, Y., et al. 2022. Food Funct. 13: 12144-12155. PMID: 36326009
  13. A multi-reference poly-conformational method for in silico design, optimization, and repositioning of pharmaceutical compounds illustrated for selected SARS-CoV-2 ligands.  |  Alexandrov, V., et al. 2022. PeerJ. 10: e14252. PMID: 36447514
  14. Advances in Polysaccharide-Based Oral Colon-Targeted Delivery Systems: The Journey So Far and the Road Ahead.  |  Ibrahim, IM. 2023. Cureus. 15: e33636. PMID: 36788847

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tegaserod Maleate, 10 mg

sc-212993
10 mg
$167.00

Tegaserod Maleate, 50 mg

sc-212993A
50 mg
$440.00