Molecular structure of Tegafur, CAS Number: 17902-23-7
Tegafur (CAS 17902-23-7)
Alternate Names:
Ftorafur
Application:
Tegafur is a congener of fluorouracil
CAS Number:
17902-23-7
Purity:
≥99%
Molecular Weight:
200.17
Molecular Formula:
C8H9FN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tegafur is chemically related to 5-fluorouracil.
Tegafur (CAS 17902-23-7) References
- Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. | Komatsu, T., et al. 2000. Drug Metab Dispos. 28: 1457-63. PMID: 11095583
- Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro. | Ikeda, K., et al. 2000. Clin Cancer Res. 6: 4409-15. PMID: 11106261
- Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur. | Murayama, N., et al. 2001. Jpn J Cancer Res. 92: 524-8. PMID: 11376561
- Sensitive liquid chromatographic assay for the simultaneous determination of 5-fluorouracil and its prodrug, tegafur, in beagle dog plasma. | Chu, D., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 795: 377-82. PMID: 14522043
- Tegafur loading and release properties of magnetite/poly(alkylcyanoacrylate) (core/shell) nanoparticles. | Arias, JL., et al. 2008. J Control Release. 125: 50-8. PMID: 17949844
- Effect of CYP2A6 genetic polymorphism on the metabolic conversion of tegafur to 5-fluorouracil and its enantioselectivity. | Yamamiya, I., et al. 2014. Drug Metab Dispos. 42: 1485-92. PMID: 25002745
- Effect of (-)-epicatechin-3-gallate and (-)-epigallocatechin-3-gallate on the binding of tegafur to human serum albumin as determined by spectroscopy, isothermal titration calorimetry, and molecular docking. | Yuan, L., et al. 2019. J Biomol Struct Dyn. 37: 2776-2788. PMID: 30101645
- Novel Pharmaceutical Cocrystals of Tegafur: Synthesis, Performance, and Theoretical Studies. | Mei, H., et al. 2024. Pharm Res. 41: 577-593. PMID: 38291166
- Effect of coadministration of uracil on the toxicity of tegafur. | Yamamoto, J., et al. 1984. J Pharm Sci. 73: 212-4. PMID: 6423805
- Advanced colorectal carcinoma: redefining the role of oral ftorafur. | Ron, IG., et al. 1996. Anticancer Drugs. 7: 649-54. PMID: 8913433
- Structure-activity relationship in Ftorafur (Tegafur) and related 5-FU prodrugs. | Zhuk, R. 1998. Adv Exp Med Biol. 431: 677-80. PMID: 9598151
Inhibitor of:
Su.Activator of:
FOXM1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tegafur, 250 mg | sc-205855 | 250 mg | $115.00 | |||
Tegafur, 1 g | sc-205855A | 1 g | $232.00 |