TDP2 Antibody (16): sc-130314
- TDP2 Antibody (16) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against recombinant TDP2 of human origin
- recommended for detection of TDP2 of mouse, rat and human origin by WB, IP and ELISA
- m-IgG2a BP-HRP is the preferred secondary detection reagent for TDP2 Antibody (16) for WB applications. This reagent is now offered in a bundle with TDP2 Antibody (16) (see ordering information below).
QUICK LINKS
SEE ALSO...
TDP2 Antibody (16) is a mouse monoclonal IgG2a antibody that detects TDP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). TDP2, also known as Ets-1-associated protein II, plays a crucial role in the regulation of Ets-1 transcriptional activity, acting as a negative modulator. This interaction is vital for maintaining the balance of gene expression, particularly in processes such as cell proliferation and differentiation. TDP2 is predominantly localized in the nucleus, where anti-TDP2 antibody (16) can detect its influence on the transcriptional landscape through modulation of Ets-1 activity, which is essential for binding to specific DNA motifs that regulate various biological functions. The phosphorylation of TDP2 is a key post-translational modification that affects its interaction with Ets-1, highlighting the importance of this regulatory mechanism in cellular signaling pathways. With its ability to interact with Ets-1 and its significant role in gene regulation, TDP2 is an important protein for researchers studying transcriptional control and its implications in various diseases. TDP2 monoclonal antibody (16) is an invaluable tool for investigating these complex interactions and understanding the underlying mechanisms of gene expression regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TDP2 Antibody (16) References:
- Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2). | Pommier, Y., et al. 2014. DNA Repair (Amst). 19: 114-29. PMID: 24856239
- ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells. | Bian, K., et al. 2016. Oncotarget. 7: 6665-75. PMID: 26701725
- TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription. | Gómez-Herreros, F., et al. 2017. Nat Commun. 8: 233. PMID: 28794467
- VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage. | Maciejewski, S., et al. 2018. Virology. 516: 139-146. PMID: 29353210
- Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors. | Kiselev, E., et al. 2020. DNA Repair (Amst). 85: 102747. PMID: 31775111
- Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation. | Holmes, AC., et al. 2020. Viruses. 12: PMID: 32023921
- Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. | Schellenberg, MJ., et al. 2020. Nucleic Acids Res. 48: 6310-6325. PMID: 32356875
- Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex. | Bhattacharjee, S., et al. 2022. DNA Repair (Amst). 111: 103277. PMID: 35101776
- Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia. | Zagnoli-Vieira, G., et al. 2023. Hum Genet. 142: 1417-1427. PMID: 37558815
- TDP2 is a regulator of estrogen-responsive oncogene expression. | Manguso, N., et al. 2024. NAR Cancer. 6: zcae016. PMID: 38596431
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TDP2 Antibody (16) | sc-130314 | 200 µg/ml | $322.00 | |||
TDP2 Antibody (16): m-IgG2a BP-HRP Bundle | sc-546017 | 200 µg Ab; 10 µg BP | $361.00 |